Nelson H Knudsen
Overview
Explore the profile of Nelson H Knudsen including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
892
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0
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Recent Articles
1.
Tsao H, Anderson S, Finn K, Perera J, Pass L, Schneider E, et al.
Immunity
. 2024 Nov;
57(12):2863-2878.e12.
PMID: 39561763
The aminopeptidase, endoplasmic reticulum aminopeptidase 1 (ERAP1), trims peptides for loading into major histocompatibility complex class I (MHC class I), and loss of this activity has broad effects on the...
2.
Baumgartner C, Ebrahimi-Nik H, Iracheta-Vellve A, Hamel K, Olander K, Davis T, et al.
Nature
. 2023 Oct;
622(7984):850-862.
PMID: 37794185
Immune checkpoint blockade is effective for some patients with cancer, but most are refractory to current immunotherapies and new approaches are needed to overcome resistance. The protein tyrosine phosphatases PTPN2...
3.
Dubrot J, Du P, Lane-Reticker S, Kessler E, Muscato A, Mehta A, et al.
Nat Immunol
. 2022 Sep;
23(10):1495-1506.
PMID: 36151395
The immune system can eliminate tumors, but checkpoints enable immune escape. Here, we identify immune evasion mechanisms using genome-scale in vivo CRISPR screens across cancer models treated with immune checkpoint...
4.
Liou Y, Personnaz J, Jacobi D, Knudsen N, Chalom M, Starost K, et al.
JCI Insight
. 2022 Jan;
7(4).
PMID: 35015731
Mitophagy and mitochondrial integrated stress response (ISR) are 2 primary protective mechanisms to maintain functional mitochondria. Whether these 2 processes are coordinately regulated remains unclear. Here we show that mitochondrial...
5.
Sun Y, Rahbani J, Jedrychowski M, Riley C, Vidoni S, Bogoslavski D, et al.
Nature
. 2021 May;
593(7860):580-585.
PMID: 33981039
Adaptive thermogenesis has attracted much attention because of its ability to increase systemic energy expenditure and to counter obesity and diabetes. Recent data have indicated that thermogenic fat cells use...
6.
Griffin G, Wu J, Iracheta-Vellve A, Patti J, Hsu J, Davis T, et al.
Nature
. 2021 May;
595(7866):309-314.
PMID: 33953401
Epigenetic dysregulation is a defining feature of tumorigenesis that is implicated in immune escape. Here, to identify factors that modulate the immune sensitivity of cancer cells, we performed in vivo...
7.
Knudsen N, Manguso R
Immunity
. 2020 Dec;
53(6):1131-1132.
PMID: 33326763
Tumors use active immunosuppressive mechanisms to evade immune recognition and shape the local inflammatory environment. In this issue of Immunity, Bonavita et al. report that tumor-derived PGE2 blocks early activation...
8.
Alexander R, Liou Y, Knudsen N, Starost K, Xu C, Hyde A, et al.
Elife
. 2020 May;
9.
PMID: 32396064
Metabolic pathways and inflammatory processes are under circadian regulation. Rhythmic immune cell recruitment is known to impact infection outcomes, but whether the circadian clock modulates immunometabolism remains unclear. We find...
9.
Knudsen N, Stanya K, Hyde A, Chalom M, Alexander R, Liou Y, et al.
Science
. 2020 May;
368(6490).
PMID: 32355002
Repeated bouts of exercise condition muscle mitochondria to meet increased energy demand-an adaptive response associated with improved metabolic fitness. We found that the type 2 cytokine interleukin-13 (IL-13) is induced...
10.
Longchamp A, Mirabella T, Arduini A, MacArthur M, Das A, Trevino-Villarreal J, et al.
Cell
. 2018 Mar;
173(1):117-129.e14.
PMID: 29570992
Angiogenesis, the formation of new blood vessels by endothelial cells (ECs), is an adaptive response to oxygen/nutrient deprivation orchestrated by vascular endothelial growth factor (VEGF) upon ischemia or exercise. Hypoxia...