Neil R Smyth
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Explore the profile of Neil R Smyth including associated specialties, affiliations and a list of published articles.
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12
Citations
280
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Recent Articles
1.
Lubomirov L, Schroeter M, Hasse V, Frohn M, Metzler D, Bust M, et al.
Front Physiol
. 2023 Apr;
14:1099278.
PMID: 37057180
Stretch-induced vascular tone is an important element of autoregulatory adaptation of cerebral vasculature to maintain cerebral flow constant despite changes in perfusion pressure. Little is known as to the regulation...
2.
Ojeda D, Hutton O, Hopkins R, Cagampang F, Smyth N, Fleming T, et al.
Brain Commun
. 2023 Apr;
5(2):fcad093.
PMID: 37033334
Poor maternal nutrition during pregnancy is known to impair fetal development. Moreover, the preimplantation period is vulnerable to adverse programming of disease. Here, we investigated the effect of a mouse...
3.
Khurana P, Cox A, Islam B, Eckert J, Willaime-Morawek S, Gould J, et al.
Stem Cell Rev Rep
. 2022 Dec;
19(3):767-783.
PMID: 36517693
Peri-conceptional environment can induce permanent changes in embryo phenotype which alter development and associate with later disease susceptibility. Thus, mouse maternal low protein diet (LPD) fed exclusively during preimplantation is...
4.
Caetano L, Eckert J, Johnston D, Chatelet D, Tumbarello D, Smyth N, et al.
Reproduction
. 2021 Aug;
162(4):289-306.
PMID: 34338217
The mouse preimplantation embryo is sensitive to its environment, including maternal dietary protein restriction, which can alter the developmental programme and affect lifetime health. Previously, we have shown maternal low-protein...
5.
Khurana P, Smyth N, Sheth B, Velazquez M, Eckert J, Fleming T
J Dev Orig Health Dis
. 2021 Jul;
13(3):395-405.
PMID: 34193331
Advanced maternal age (AMA) is known to reduce fertility, increases aneuploidy in oocytes and early embryos and leads to adverse developmental consequences which may associate with offspring lifetime health risks....
6.
Aljahdali A, Airina R, Velazquez M, Sheth B, Wallen K, Osmond C, et al.
Hum Reprod
. 2020 Oct;
35(11):2497-2514.
PMID: 33020802
Study Question: Do the long-term health outcomes following IVF differ depending upon the duration of embryo culture before transfer? Summary Answer: Using a mouse model, we demonstrate that in male...
7.
Vilela P, Heuer-Jungemann A, El-Sagheer A, Brown T, Muskens O, Smyth N, et al.
Small
. 2018 Feb;
14(12):e1703489.
PMID: 29464860
Wound healing is a highly complex biological process, which is accompanied by changes in cell phenotype, variations in protein expression, and the production of active biomolecules. Currently, the detection of...
8.
Keable A, Fenna K, Yuen H, Johnston D, Smyth N, Smith C, et al.
Biochim Biophys Acta
. 2015 Sep;
1862(5):1037-46.
PMID: 26327684
Deposition of amyloid β (Aβ) in the walls of cerebral arteries as cerebral amyloid angiopathy (CAA) suggests an age-related failure of perivascular drainage of soluble Aβ from the brain. As...
9.
Roghanian A, Teige I, Martensson L, Cox K, Kovacek M, Ljungars A, et al.
Cancer Cell
. 2015 Apr;
27(4):473-88.
PMID: 25873171
Therapeutic antibodies have transformed cancer therapy, unlocking mechanisms of action by engaging the immune system. Unfortunately, cures rarely occur and patients display intrinsic or acquired resistance. Here, we demonstrate the...
10.
Fleming T, Watkins A, Sun C, Velazquez M, Smyth N, Eckert J
Reprod Fertil Dev
. 2015 Mar;
27(4):684-92.
PMID: 25730413
Periconceptional environment may influence embryo development, ultimately affecting adult health. Here, we review the rodent model of maternal low-protein diet specifically during the preimplantation period (Emb-LPD) with normal nutrition during...