Neelesh Kumar Mehra
Overview
Explore the profile of Neelesh Kumar Mehra including associated specialties, affiliations and a list of published articles.
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Articles
83
Citations
690
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Recent Articles
11.
Kumari N, Sandeep Chary P, Pardhi E, Mehra N
Nanomedicine (Lond)
. 2024 May;
19(13):1145-1166.
PMID: 38700294
To investigate the pemetrexed encapsulated polymeric mixed micelles (PMMs) against breast cancer treatment. We meticulously optimized the formulation and conducted extensive characterizations, including photon correlation spectroscopy for micellization, advanced analytical...
12.
Sandeep Chary P, Bansode A, Rajana N, Bhavana V, Singothu S, Sharma A, et al.
Int J Pharm
. 2024 Apr;
657:124109.
PMID: 38626846
Breast cancer continues to pose a substantial global health challenge, emphasizing the critical need for the advancement of novel therapeutic approaches. Key players in the regulation of apoptosis, a fundamental...
13.
Yadav R, Mahajan S, Singh H, Mehra N, Madan J, Doijad N, et al.
Adv Biol (Weinh)
. 2024 Apr;
8(6):e2300487.
PMID: 38581078
Various cancer models have been developed to aid the understanding of the underlying mechanisms of tumor development and evaluate the effectiveness of various anticancer drugs in preclinical studies. These models...
14.
Patil R, Srivastava V, Bhawale R, Tryphena K, Khatri D, Doijad N, et al.
Nanomedicine (Lond)
. 2024 Mar;
19(11):947-964.
PMID: 38483291
This study aims to explore potential of transniosomes, a hybrid vesicular system, as ocular drug-delivery vehicle. Thin-film hydration technique was used to fabricate brinzolamide-loaded transniosomes (BRZ-TN) and optimized using Box-Behnken...
15.
Yadav R, Bhawale R, Srivastava V, Pardhi E, Bhalerao H, Sonti R, et al.
AAPS PharmSciTech
. 2024 Mar;
25(3):52.
PMID: 38429601
As a major public health issue, colorectal cancer causes 9.4% of total cancer-related deaths and comprises 10% of new cancer diagnoses worldwide. In the year 2023, an estimated 153,020 people...
16.
Kumari N, Pardhi E, Sandeep Chary P, Mehra N
Ther Deliv
. 2024 Feb;
15(4):279-303.
PMID: 38374774
Breast cancer (BC) is a heterogeneous disease with various morphological features, clinicopathological conditions and responses to different therapeutic options, which is responsible for high mortality and morbidity in women. The...
17.
Raju B, Narendra G, Verma H, Kumar M, Sapra B, Kaur G, et al.
J Biomol Struct Dyn
. 2024 Feb;
:1-19.
PMID: 38356135
Cytochrome P450 1B1, a tumor-specific overexpressed enzyme, significantly impairs the pharmacokinetics of several commonly used anticancer drugs including docetaxel, paclitaxel and cisplatin, leading to the problem of resistance to these...
18.
Samia S, Sandeep Chary P, Khan O, Mehra N
Int J Pharm
. 2024 Feb;
653:123889.
PMID: 38346605
Breast cancer (BC) remains a significant health burden worldwide, necessitating the development of innovative therapeutic strategies. The B-cell lymphoma 2 (Bcl-2) family proteins, Bcl-2 and Bax, play a crucial role...
19.
Pardhi E, Vasave R, Srivastava V, Yadav R, Mehra N
Drug Discov Today
. 2024 Feb;
29(3):103913.
PMID: 38340952
The pharmaceutical industry is grappling with a pressing crisis in drug development characterized by soaring R&D costs, setbacks in blockbuster drug development due to poor aqueous solubility, and patent-related limitations...
20.
Pardhi E, Tomar D, Khemchandani R, Bazaz M, Dandekar M, Samanthula G, et al.
J Biomol Struct Dyn
. 2024 Feb;
:1-30.
PMID: 38299571
Study aimed to design and development of a supramolecular formulation of sulpiride (SUL) to enhance its solubility, dissolution and permeability by targeting a novel GlyT1 inhibition mechanism. SUL is commonly...