Neal LeLeiko
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Explore the profile of Neal LeLeiko including associated specialties, affiliations and a list of published articles.
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51
Citations
2754
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Recent Articles
1.
Whaley K, Xiong Y, Karns R, Hyams J, Kugathasan S, Boyle B, et al.
Clin Gastroenterol Hepatol
. 2022 Aug;
21(5):1338-1347.
PMID: 36031093
Background & Aims: We aimed to model infliximab (IFX) pharmacokinetics (PK) in pediatric acute severe ulcerative colitis (ASUC) and assess the association between PK parameters, including drug exposure, and clinical...
2.
Kerur B, Fiedler K, Stahl M, Hyams J, Stephens M, Lu Y, et al.
J Pediatr Gastroenterol Nutr
. 2022 May;
75(1):64-69.
PMID: 35622080
Background: Research on the utilization and effectiveness of antitumor necrosis factor (TNF) biologics in children with very early onset inflammatory bowel disease (VEOIBD) is urgently needed. Here we describe anti-TNF...
3.
Hyams J, Brimacombe M, Haberman Y, Walters T, Gibson G, Mo A, et al.
Inflamm Bowel Dis
. 2021 Apr;
28(2):151-160.
PMID: 33904583
Background: Develop a clinical and biological predictive model for colectomy risk in children newly diagnosed with ulcerative colitis (UC). Methods: This was a multicenter inception cohort study of children (ages...
4.
Haberman Y, Minar P, Karns R, Dexheimer P, Ghandikota S, Tegge S, et al.
J Crohns Colitis
. 2020 Aug;
PMID: 32770196
Background And Aims: Ileal strictures are the major indication for resective surgery in Crohn's disease (CD). We aimed to define ileal gene programs present at diagnosis linked with future stricturing...
5.
Mack D, Saul B, Boyle B, Griffiths A, Sauer C, Markowitz J, et al.
J Pediatr Gastroenterol Nutr
. 2020 Jun;
71(3):354-360.
PMID: 32520830
Objectives: The aim of this study was to assess common laboratory tests in identifying severe ulcerative colitis in children at diagnosis. Methods: A cohort of 427 children 4 to 17...
6.
Kerur B, Benchimol E, Fiedler K, Stahl M, Hyams J, Stephens M, et al.
Inflamm Bowel Dis
. 2020 May;
27(3):295-302.
PMID: 32386060
Background: The incidence of very early onset inflammatory bowel disease (VEOIBD) is increasing, yet the phenotype and natural history of VEOIBD are not well described. Methods: We performed a retrospective...
7.
Haberman Y, Schirmer M, Dexheimer P, Karns R, Braun T, Kim M, et al.
Mucosal Immunol
. 2018 Dec;
12(2):491-502.
PMID: 30542108
Age-of-diagnosis associated variation in disease location and antimicrobial sero-reactivity has suggested fundamental differences in pediatric Crohn Disease (CD) pathogenesis. This variation may be related to pubertal peak incidence of ileal...
8.
Schirmer M, Denson L, Vlamakis H, Franzosa E, Thomas S, Gotman N, et al.
Cell Host Microbe
. 2018 Oct;
24(4):600-610.e4.
PMID: 30308161
Evaluating progression risk and determining optimal therapy for ulcerative colitis (UC) is challenging as many patients exhibit incomplete responses to treatment. As part of the PROTECT (Predicting Response to Standardized...
9.
Lindoso L, Mondal K, Venkateswaran S, Somineni H, Ballengee C, Walters T, et al.
Am J Gastroenterol
. 2018 Sep;
113(10):1524-1529.
PMID: 30267029
Objectives: Environmental factors play an important role in the pathogenesis of Crohn's Disease (CD). In particular, by virtue of the instability of the microbiome and development of immunologic tolerance, early...
10.
Lu S, Herzlinger M, Cao W, Noble L, Yang D, Shapiro J, et al.
Sci Rep
. 2018 Sep;
8(1):14498.
PMID: 30266946
The pathogenesis of eosinophilic esophagitis (EoE) involves Th2-mediated eosinophil recruitment and degranulation into the esophagus. However, measuring serum Th2 cytokines, eosinophils, and eosinophil-derived products does not reliably distinguish EoE from...