Nazem Atassi
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Explore the profile of Nazem Atassi including associated specialties, affiliations and a list of published articles.
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75
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1768
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Recent Articles
1.
Hincelin-Mery A, Nicolas X, Cantalloube C, Pomponio R, Lewanczyk P, Benamor M, et al.
Clin Transl Sci
. 2023 Nov;
17(1):e13690.
PMID: 38010108
SAR443820 (DNL788) is a selective, orally bioavailable, brain penetrant inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1). This phase I first-in-human healthy participant study (NCT05795907) was comprised of three parts:...
2.
Querol L, Lewis R, Hartung H, van Doorn P, Wallstroem E, Luo X, et al.
J Peripher Nerv Syst
. 2023 Apr;
28(2):276-285.
PMID: 37119056
Background And Aims: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare immune-mediated disease of the peripheral nerves, with significant unmet treatment needs. Clinical trials in CIDP are challenging; thus, new...
3.
Rumsey J, Lorance C, Jackson M, Sasserath T, McAleer C, Long C, et al.
Adv Ther (Weinh)
. 2022 Oct;
5(6).
PMID: 36211621
Chronic autoimmune demyelinating neuropathies are a group of rare neuromuscular disorders with complex, poorly characterized etiology. Here we describe a phenotypic, human-on-a-chip (HoaC) electrical conduction model of two rare autoimmune...
4.
Barry R, Torrado-Carvajal A, Kirsch J, Arabasz G, Albrecht D, Alshelh Z, et al.
Neuroimage Clin
. 2022 Sep;
36:103199.
PMID: 36137496
Amyotrophic lateral sclerosis (ALS) is a deadly neurodegenerative disorder affecting motor neurons in the spinal cord and brain. Studies have reported on atrophy within segments of the cervical cord, but...
5.
Vissers M, Heuberger J, Groeneveld G, Oude Nijhuis J, De Deyn P, Hadi S, et al.
Clin Transl Sci
. 2022 Jun;
15(8):2010-2023.
PMID: 35649245
RIPK1 is a master regulator of inflammatory signaling and cell death and increased RIPK1 activity is observed in human diseases, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). RIPK1...
6.
Querol L, Hartung H, Lewis R, van Doorn P, Hammond T, Atassi N, et al.
Neurotherapeutics
. 2022 Apr;
19(3):864-873.
PMID: 35378684
Chronic inflammatory demyelinating polyneuropathy (CIDP) is the most common, heterogeneous, immune-mediated neuropathy, characterized by predominant demyelination of motor and sensory nerves. CIDP follows a relapsing-remitting or a progressive course and...
7.
Milligan C, Atassi N, Babu S, Barohn R, Caress J, Cudkowicz M, et al.
Muscle Nerve
. 2021 Jun;
64(3):309-320.
PMID: 34075589
Introduction/aims: We tested safety, tolerability, and target engagement of tocilizumab in amyotrophic lateral sclerosis (ALS) patients. Methods: Twenty-two participants, whose peripheral blood mononuclear cell (PBMC) gene expression profile reflected high...
8.
Ibudilast (MN-166) in amyotrophic lateral sclerosis- an open label, safety and pharmacodynamic trial
Babu S, Hightower B, Chan J, Zurcher N, Kivisakk P, Tseng C, et al.
Neuroimage Clin
. 2021 May;
30:102672.
PMID: 34016561
Ibudilast (MN-166) is an inhibitor of macrophage migration inhibitory factor (MIF) and phosphodiesterases 3,4,10 and 11 (Gibson et al., 2006; Cho et al., 2010). Ibudilast attenuates CNS microglial activation and...
9.
Barry R, Babu S, Anteraper S, Triantafyllou C, Keil B, Rowe O, et al.
Neuroimage Clin
. 2021 Apr;
30:102648.
PMID: 33872993
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the central nervous system that results in a progressive loss of motor function and ultimately death. It is critical, yet also...
10.
Makary M, Weerasekara A, Rodham H, Hightower B, Tseng C, Chan J, et al.
ACS Chem Neurosci
. 2021 Feb;
12(5):906-916.
PMID: 33576234
Several clinical upper motor neuron burden scales (UMNSs) variably measure brain dysfunction in amyotrophic lateral sclerosis (ALS). Here, we compare relationship of two widely used clinical UMNSs in ALS (Penn...