Nayara C Leite
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Explore the profile of Nayara C Leite including associated specialties, affiliations and a list of published articles.
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12
Citations
221
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Recent Articles
1.
Bochenek M, Walters B, Zhang J, Fenton O, Facklam A, Kronekova Z, et al.
Small
. 2024 Jan;
20(23):e2307464.
PMID: 38212275
The transplantation of immunoisolated stem cell derived beta cell clusters (SC-β) has the potential to restore physiological glycemic control in patients with type I diabetes. This strategy is attractive as...
2.
Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro
Leite N, Pelayo G, Melton D
Stem Cell Reports
. 2022 Mar;
17(4):766-774.
PMID: 35245439
The in vitro production of stem-cell-derived islets (SC-islets) has brought forth the potential of transplanting these cells to restore glycemic control in people with diabetes. Nonetheless, alloimmune and autoimmune responses...
3.
Huang L, Desai R, Conrad D, Leite N, Akshinthala D, Maria Lim C, et al.
Cell Stem Cell
. 2021 Apr;
28(6):1090-1104.e6.
PMID: 33915081
The exocrine pancreas, consisting of ducts and acini, is the site of origin of pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and progression of human pancreatic...
4.
Ferreira S, Costa-Junior J, Kurauti M, Leite N, Ortis F, Rezende L, et al.
Front Endocrinol (Lausanne)
. 2020 Dec;
11:599165.
PMID: 33324349
ARHGAP21 is a RhoGAP protein implicated in the modulation of insulin secretion and energy metabolism. ARHGAP21 transient-inhibition increase glucose-stimulated insulin secretion (GSIS) in neonatal islets; however, ARHGAP21 heterozygote mice have...
5.
Cai E, Ishikawa Y, Zhang W, Leite N, Li J, Hou S, et al.
Nat Metab
. 2020 Jul;
2(9):934-945.
PMID: 32719542
Type 1 diabetes (T1D) is caused by the autoimmune destruction of pancreatic beta cells. Pluripotent stem cells can now be differentiated into beta cells, thus raising the prospect of a...
6.
Leite N, Sintov E, Meissner T, Brehm M, Greiner D, Harlan D, et al.
Cell Rep
. 2020 Jul;
32(2):107894.
PMID: 32668238
Understanding the root causes of autoimmune diseases is hampered by the inability to access relevant human tissues and identify the time of disease onset. To examine the interaction of immune...
7.
Guareschi Z, Valcanaia A, Ceglarek V, Hotz P, Amaral B, de Souza D, et al.
Br J Nutr
. 2019 Mar;
121(12):1334-1344.
PMID: 30924427
Reduced plasma vitamin D (VD) levels may contribute to excessive white adipose tissue, insulin resistance (IR) and dyslipidaemia. We evaluated the effect of chronic oral VD supplementation on adiposity and...
8.
de Souza Santos R, Camargo R, Vanzela E, Batista T, Morato P, Leite N, et al.
Amino Acids
. 2017 Dec;
50(3-4):469-477.
PMID: 29282544
Low levels of estrogens are associated with obesity-related comorbidities. Mice with lower levels of estrogens are thereby more sensitive to the effects of a high-fat-diet (HFD) for the development of...
9.
Paula F, Leite N, Borck P, Freitas-Dias R, Cnop M, Chacon-Mikahil M, et al.
FASEB J
. 2017 Nov;
32(3):1524-1536.
PMID: 29133342
Prolonged exercise has positive metabolic effects in obese or diabetic individuals. These effects are usually ascribed to improvements in insulin sensitivity. We evaluated whether exercise also generates circulating signals that...
10.
Santos R, Batista T, Camargo R, Morato P, Borck P, Leite N, et al.
Steroids
. 2016 May;
114:16-24.
PMID: 27192429
Low levels of plasma estrogens are associated with weight-gain, android fat distribution, and a high prevalence of obesity-related comorbidities such as glucose intolerance and type II diabetes. The mechanisms underlying...