Nathan Waal
Overview
Explore the profile of Nathan Waal including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
72
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0
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Recent Articles
1.
Boyd M, Collier P, Clark M, Deng H, Kesavan S, Ronkin S, et al.
J Med Chem
. 2021 Dec;
64(24):17777-17794.
PMID: 34871500
In our efforts to identify novel small molecule inhibitors for the treatment of adrenoleukodystrophy (ALD), we conducted a high-throughput radiometric screen for inhibitors of elongation of very long chain fatty...
2.
Tang Q, Aronov A, Deininger D, Giroux S, Lauffer D, Li P, et al.
ACS Med Chem Lett
. 2021 Jun;
12(6):955-960.
PMID: 34141080
Herein, we report a novel series of highly potent and selective triazolothiadiazole c-Met inhibitors. Starting with molecule , we have applied structure-based drug design principles to identify the triazolothiadiazole ring...
3.
Grillot A, Le Tiran A, Shannon D, Krueger E, Liao Y, ODowd H, et al.
J Med Chem
. 2014 Oct;
57(21):8792-816.
PMID: 25317480
Compound 3 is a potent aminobenzimidazole urea with broad-spectrum Gram-positive antibacterial activity resulting from dual inhibition of bacterial gyrase (GyrB) and topoisomerase IV (ParE), and it demonstrates efficacy in rodent...
4.
Braisted A, Oslob J, DeLano W, Hyde J, McDowell R, Waal N, et al.
J Am Chem Soc
. 2003 Mar;
125(13):3714-5.
PMID: 12656598
Using a site-directed fragment discovery method called tethering, we have identified a 60 nM small molecule antagonist of a cytokine/receptor interaction (IL-2/IL2Ralpha) with cell-based activity. Starting with a low micromolar...