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Nathan D Roe

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Articles 16
Citations 756
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Recent Articles
1.
Turdi S, Han X, Huff A, Roe N, Hu N, Gao F, et al.
Free Radic Biol Med . 2022 Aug; 189:178. PMID: 35927165
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief. After an institutional investigation into the...
2.
Shao D, Kolwicz Jr S, Wang P, Roe N, Villet O, Nishi K, et al.
Circulation . 2020 Jun; 142(10):983-997. PMID: 32597196
Background: Increased fatty acid oxidation (FAO) has long been considered a culprit in the development of obesity/diabetes mellitus-induced cardiomyopathy. However, enhancing cardiac FAO by removing the inhibitory mechanism of long-chain...
3.
Roe N, Handzlik M, Li T, Tian R
Sci Rep . 2018 Mar; 8(1):4983. PMID: 29563512
It is increasingly recognized that synthesis and turnover of cardiac triglyceride (TG) play a pivotal role in the regulation of lipid metabolism and function of the heart. The last step...
4.
Li T, Zhang Z, Kolwicz Jr S, Abell L, Roe N, Kim M, et al.
Cell Metab . 2017 Feb; 25(2):374-385. PMID: 28178567
Elevated levels of branched-chain amino acids (BCAAs) have recently been implicated in the development of cardiovascular and metabolic diseases, but the molecular mechanisms are unknown. In a mouse model of...
5.
Lee C, Chavez J, Garcia-Menendez L, Choi Y, Roe N, Chiao Y, et al.
Circulation . 2016 Aug; 134(12):883-94. PMID: 27489254
Background: Impairments of mitochondrial function in the heart are linked intricately to the development of heart failure, but there is no therapy for mitochondrial dysfunction. Methods: We assessed the reduced/oxidized...
6.
Roe N, Standage S, Tian R
Circ Res . 2016 Feb; 118(2):193-5. PMID: 26838311
No abstract available.
7.
Roe N, Xu X, Kandadi M, Hu N, Pang J, Weiser-Evans M, et al.
Biochim Biophys Acta . 2014 Sep; 1852(2):290-8. PMID: 25229693
Phosphatase and tensin homolog (PTEN) deleted from chromosome 10 has been implicated in the maintenance of cardiac homeostasis although the underlying mechanism(s) remains elusive. We generated a murine model of...
8.
Kandadi M, Panzhinskiy E, Roe N, Nair S, Hu D, Sun A
Biochim Biophys Acta . 2014 Jul; 1852(2):299-309. PMID: 25018087
Obesity-induced cardiomyopathy may be mediated by alterations in multiple signaling cascades involved in glucose and lipid metabolism. Protein tyrosine phosphatase-1B (PTP1B) is an important negative regulator of insulin signaling. This...
9.
Xu X, Roe N, Weiser-Evans M, Ren J
Hypertension . 2014 Jan; 63(4):729-39. PMID: 24446058
The role of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) in the maintenance of cardiac homeostasis still remains controversial. This study was designed to evaluate the role of...
10.
Roe N, He E, Wu Z, Ren J
Free Radic Biol Med . 2013 Jul; 65:234-243. PMID: 23820268
Nitric oxide synthase (NOS) may be uncoupled to produce superoxide rather than nitric oxide (NO) under pathological conditions such as diabetes mellitus and insulin resistance, leading to cardiac contractile anomalies....