Nathalie J van Orsouw
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Explore the profile of Nathalie J van Orsouw including associated specialties, affiliations and a list of published articles.
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7
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328
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Recent Articles
1.
Hogers R, de Ruiter M, Huvenaars K, van der Poel H, Janssen A, van Eijk M, et al.
PLoS One
. 2018 Oct;
13(10):e0205577.
PMID: 30312324
In plant breeding the use of molecular markers has resulted in tremendous improvement of the speed with which new crop varieties are introduced into the market. Single Nucleotide Polymorphism (SNP)...
2.
van Poecke R, Maccaferri M, Tang J, Truong H, Janssen A, van Orsouw N, et al.
Plant Biotechnol J
. 2013 May;
11(7):809-17.
PMID: 23639032
Marker development for marker-assisted selection in plant breeding is increasingly based on next-generation sequencing (NGS). However, marker development in crops with highly repetitive, complex genomes is still challenging. Here we...
3.
Truong H, Ramos A, Yalcin F, de Ruiter M, van der Poel H, Huvenaars K, et al.
PLoS One
. 2012 Jun;
7(5):e37565.
PMID: 22662172
Conventional marker-based genotyping platforms are widely available, but not without their limitations. In this context, we developed Sequence-Based Genotyping (SBG), a technology for simultaneous marker discovery and co-dominant scoring, using...
4.
Rigola D, van Oeveren J, Janssen A, Bonne A, Schneiders H, van der Poel H, et al.
PLoS One
. 2009 Mar;
4(3):e4761.
PMID: 19283079
Reverse genetics approaches rely on the detection of sequence alterations in target genes to identify allelic variants among mutant or natural populations. Current (pre-) screening methods such as TILLING and...
5.
van Orsouw N, Hogers R, Janssen A, Yalcin F, Snoeijers S, Verstege E, et al.
PLoS One
. 2007 Nov;
2(11):e1172.
PMID: 18000544
Application of single nucleotide polymorphisms (SNPs) is revolutionizing human bio-medical research. However, discovery of polymorphisms in low polymorphic species is still a challenging and costly endeavor, despite widespread availability of...
6.
Andrulis I, Anton-Culver H, Beck J, Bove B, Boyd J, Buys S, et al.
Hum Mutat
. 2002 Jul;
20(1):65-73.
PMID: 12112659
A number of methods are used for mutational analysis of BRCA1, a large multi-exon gene. A comparison was made of five methods to detect mutations generating premature stop codons that...
7.
Nekhaeva E, Bodyak N, Kraytsberg Y, McGrath S, van Orsouw N, Pluzhnikov A, et al.
Proc Natl Acad Sci U S A
. 2002 Apr;
99(8):5521-6.
PMID: 11943860
Using single-cell sequence analysis, we discovered that a high proportion of cells in tissues as diverse as buccal epithelium and heart muscle contain high proportions of clonal mutant mtDNA expanded...