Narayan Prasad Parajuli
Overview
Explore the profile of Narayan Prasad Parajuli including associated specialties, affiliations and a list of published articles.
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18
Citations
261
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Recent Articles
1.
Parajuli N, Emmerich A, Mandava C, Pavlov M, Sanyal S
Nat Commun
. 2023 Feb;
14(1):918.
PMID: 36806263
Thermorubin (THB) is a long-known broad-spectrum ribosome-targeting antibiotic, but the molecular mechanism of its action was unclear. Here, our precise fast-kinetics assays in a reconstituted Escherichia coli translation system and...
2.
Parajuli N, Mandava C, Pavlov M, Sanyal S
Nucleic Acids Res
. 2021 Jun;
49(12):6880-6892.
PMID: 34125898
How aminoglycoside antibiotics limit bacterial growth and viability is not clearly understood. Here we employ fast kinetics to reveal the molecular mechanism of action of a clinically used, new-generation, semisynthetic...
3.
De Tarafder A, Parajuli N, Majumdar S, Kacar B, Sanyal S
Mol Biol Evol
. 2021 Apr;
38(8):3436-3444.
PMID: 33871630
It has been hypothesized that early enzymes are more promiscuous than their extant orthologs. Whether or not this hypothesis applies to the translation machinery, the oldest molecular machine of life,...
4.
Pandit R, Awal B, Shrestha S, Joshi G, Rijal B, Parajuli N
Interdiscip Perspect Infect Dis
. 2020 May;
2020:6525826.
PMID: 32377184
Urinary tract infections (UTI) represent the most common bacterial infections among patients visiting outpatient clinics of healthcare centers in Nepal. However, treatment of such infections is compounded by emergence and...
5.
Maharjan A, Bhetwal A, Shakya S, Satyal D, Shah S, Joshi G, et al.
Infect Drug Resist
. 2018 May;
11:547-554.
PMID: 29731643
Background: Fecal carriage of multidrug-resistant and extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae is one of the important risk factors for infection with antibiotic-resistant bacteria. In this report, we examined the prevalence of...
6.
Bhetwal A, Maharjan A, Shakya S, Satyal D, Ghimire S, Khanal P, et al.
Biomed Res Int
. 2018 Jan;
2017:3723254.
PMID: 29359149
Bacteriophages are being the subject of interest for alternative antimicrobial therapy for infectious diseases in recent years. Therapeutic effectiveness regarding phage therapy is a matter of concern since it is...
7.
Bhetwal A, Maharjan A, Khanal P, Parajuli N
Int J Microbiol
. 2017 Dec;
2017:2869458.
PMID: 29234353
Enteric fever continues to be an important public health problem especially in developing countries of the tropical region including Nepal. In this study, we aimed to investigate the incidence of...
8.
Khanal P, Satyal D, Bhetwal A, Maharjan A, Shakya S, Tandukar S, et al.
Biomed Res Int
. 2017 Oct;
2017:2868143.
PMID: 29018810
Enteric fever caused by is a life-threatening systemic illness of gastrointestinal tract especially in tropical countries. Antimicrobial therapy is generally indicated but resistance towards commonly used antibiotics has limited their...
9.
Rijal B, Satyal D, Parajuli N
J Pathog
. 2017 Sep;
2017:9458218.
PMID: 28932604
Pyogenic wound infections are one of the most common clinical entities caused and aggravated by the invasion of pathogenic organisms. Prompt and aggressive antimicrobial therapy is needed to reduce the...
10.
Parajuli N, Acharya S, Mishra S, Parajuli K, Rijal B, Pokhrel B
Antimicrob Resist Infect Control
. 2017 Jun;
6:67.
PMID: 28638594
Background: Healthcare associated infections (HCAI) and antimicrobial resistance are principal threats to the patients of intensive care units and are the major determining factors for patient outcome. They are associated...