Naoto Shikano
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Explore the profile of Naoto Shikano including associated specialties, affiliations and a list of published articles.
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44
Citations
206
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Recent Articles
1.
Mizutani A, Kobayashi M, Nishi K, Fujita K, Takahashi K, Muranaka Y, et al.
Front Pharmacol
. 2024 Jul;
15:1397288.
PMID: 38962307
As drug-metabolizing enzyme activities are affected by a variety of factors, such as drug-drug interactions, a method to evaluate drug-metabolizing enzyme activities in real time is needed. In this study,...
2.
Tani T, Fujita T, Misawa M, Tojo N, Shikano N, Suzuki M, et al.
Radiat Res
. 2023 May;
200(1):21-31.
PMID: 37212749
This study conducted fundamental research to develop a more effective BNCT targeting cancer stem cells. We constructed plasmids that induced the overexpression of L-type amino acid transporter 1 (LAT1) tagged...
3.
Muranaka Y, Matsue M, Mizutani A, Kobayashi M, Sato K, Kondo A, et al.
Int J Mol Sci
. 2023 Mar;
24(5).
PMID: 36902204
The World Health Organization has cautioned that antimicrobial resistance (AMR) will be responsible for an estimated 10 million deaths annually by 2050. To facilitate prompt and accurate diagnosis and treatment...
4.
Mizutani A, Kobayashi M, Aibe R, Muranaka Y, Nishi K, Kitamura M, et al.
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36232758
Drug metabolizing enzyme activity is affected by various factors such as drug-drug interactions, and a method to quantify drug metabolizing enzyme activity in real time is needed. In this study,...
5.
Muranaka Y, Mizutani A, Kobayashi M, Nakamoto K, Matsue M, Takagi F, et al.
Pharmaceutics
. 2022 May;
14(5).
PMID: 35631596
In this study, we evaluated the use of 15-(4-I-iodophenyl)-3(R,S)-methylpentadecanoic acid (I-BMIPP) to visualize fatty acid metabolism in bacteria for bacterial infection imaging. We found that I-BMIPP, which is used for...
6.
Muranaka Y, Mizutani A, Kobayashi M, Nakamoto K, Matsue M, Nishi K, et al.
Int J Mol Sci
. 2022 Mar;
23(5).
PMID: 35269610
The effectiveness of L- and D-amino acids for detecting the early stage of infection in bacterial imaging was compared. We evaluated the accumulation of H-L-methionine (Met), H-D-Met, H-L-alanine (Ala), and...
7.
Kobayashi M, Mizutani A, Muranaka Y, Nishi K, Komori H, Nishii R, et al.
Pharmaceutics
. 2022 Jan;
14(1).
PMID: 35056957
Gastrointestinal tract absorption of cationic anticancer drugs and medicines was estimated using whole-body imaging following oral [I]MIBG administration. [I]MIBG was added to cultures of human embryonic kidney (HEK)293 cells expressing...
8.
Kobayashi M, Mizutani A, Okamoto T, Muranaka Y, Nishi K, Nishii R, et al.
Nucl Med Biol
. 2021 Feb;
94-95:92-97.
PMID: 33609918
Introduction: We clarified the renal uptake and urinary secretion mechanism of [Tc]dimercaptosuccinic acid ([Tc]DMSA) via drug transporters in renal proximal tubules. Methods: [Tc]DMSA was added to human embryonic kidney 293...
9.
Kobayashi M, Mizutani A, Nishi K, Muranaka Y, Nishii R, Shikano N, et al.
Nucl Med Biol
. 2020 Oct;
90-91:49-54.
PMID: 33032192
Introduction: I-labeled m-iodobenzylguanidine ([I]MIBG) has been used to treat neuroblastoma patients, but [I]MIBG may be immediately excreted from the cancer cells by the adenosine triphosphate binding cassette transporters, similar to...
10.
Kobayashi M, Nishi K, Mizutani A, Okudaira H, Nakanishi T, Shikano N, et al.
Nucl Med Biol
. 2020 Jan;
84-85:33-37.
PMID: 31986465
Technetium-99m-labeled mercaptoacetyltriglycine ([Tc]MAG3) is widely used for evaluation of transplanted kidneys, diagnosis of tubular necrosis, and scintigraphic studies of tubular function. [Tc]MAG3 is a substrate for organic anion transporter (OAT)1...