Naoto Muraoka
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Explore the profile of Naoto Muraoka including associated specialties, affiliations and a list of published articles.
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23
Citations
1707
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Recent Articles
1.
Li Z, LaPenna K, Gehred N, Yu X, Tang W, Doiron J, et al.
bioRxiv
. 2025 Jan;
PMID: 39763741
Background: Recent reports suggest increased myocardial iNOS expression leads to excessive protein -nitrosylation, contributing to the pathophysiology of HFpEF. However, the relationship between NO bioavailability, dynamic regulation of protein -nitrosylation...
2.
Doiron J, Elbatreek M, Xia H, Yu X, Gehred N, Gromova T, et al.
bioRxiv
. 2024 Sep;
PMID: 39345440
Background: Heart failure with preserved ejection fraction (HFpEF) is a significant public health concern with limited treatment options. Dysregulated nitric oxide-mediated signaling has been implicated in HFpEF pathophysiology, however, little...
3.
Yoshii A, McMillen T, Wang Y, Zhou B, Chen H, Banerjee D, et al.
Circ Res
. 2024 Sep;
135(10):1004-1017.
PMID: 39328167
Background: Metabolic remodeling and mitochondrial dysfunction are hallmarks of heart failure with reduced ejection fraction. However, their role in the pathogenesis of HF with preserved ejection fraction (HFpEF) is poorly...
4.
Kojima H, Sadahiro T, Muraoka N, Yamakawa H, Hashimoto H, Ishii R, et al.
Stem Cell Reports
. 2023 Jun;
18(6):1274-1283.
PMID: 37315521
Cardiac transcription factors (TFs) directly reprogram fibroblasts into induced cardiomyocytes (iCMs), where MEF2C acts as a pioneer factor with GATA4 and TBX5 (GT). However, the generation of functional and mature...
5.
Toyosaki M, Homma K, Suzuki S, Muraoka N, Hashimoto H, Goshima N, et al.
Sci Rep
. 2020 Dec;
10(1):21467.
PMID: 33293623
In deep burns, early wound closure is important for healing, and skin grafting is mainly used for wound closure. However, it is difficult to achieve early wound closure in extensive...
6.
Kurotsu S, Sadahiro T, Fujita R, Tani H, Yamakawa H, Tamura F, et al.
Stem Cell Reports
. 2020 Aug;
15(3):612-628.
PMID: 32857980
Direct cardiac reprogramming holds great potential for regenerative medicine. However, it remains inefficient, and induced cardiomyocytes (iCMs) generated in vitro are less mature than those in vivo, suggesting that undefined...
7.
Karbassi E, Fenix A, Marchiano S, Muraoka N, Nakamura K, Yang X, et al.
Nat Rev Cardiol
. 2020 Feb;
17(6):341-359.
PMID: 32015528
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we now can generate most cells of the human body in the laboratory. PSC-derived cardiomyocytes can...
8.
Muraoka N, Sun B, Murry C
Circ Res
. 2019 Nov;
125(11):954-956.
PMID: 31697629
No abstract available.
9.
Haginiwa S, Sadahiro T, Kojima H, Isomi M, Tamura F, Kurotsu S, et al.
Biochem Biophys Res Commun
. 2019 Apr;
513(4):1041-1047.
PMID: 31010673
Cardiovascular disease is a leading cause of death worldwide. Mammalian cardiomyocytes (CMs) proliferate during embryonic development, whereas they largely lose their regenerative capacity after birth. Defined factors expressed in cardiac...
10.
Muraoka N, Nara K, Tamura F, Kojima H, Yamakawa H, Sadahiro T, et al.
Nat Commun
. 2019 Feb;
10(1):674.
PMID: 30787297
Direct cardiac reprogramming from fibroblasts can be a promising approach for disease modeling, drug screening, and cardiac regeneration in pediatric and adult patients. However, postnatal and adult fibroblasts are less...