Naomi Goldman
Overview
Explore the profile of Naomi Goldman including associated specialties, affiliations and a list of published articles.
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17
Citations
271
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Recent Articles
1.
Dimitri A, Baxter A, Chen G, Hopkins C, Rouin G, Huang H, et al.
Sci Adv
. 2024 Nov;
10(46):eadp9371.
PMID: 39536093
CD8 T cell exhaustion hampers control of cancer and chronic infections and limits chimeric antigen receptor (CAR) T cell efficacy. Targeting in CAR T cells provides therapeutic benefit; however, TET2's...
2.
Maslanka J, Torres G, Londregan J, Goldman N, Silberman D, Somerville J, et al.
Cell Immunol
. 2023 Nov;
395-396:104788.
PMID: 38000306
Recent advances in immunotherapy have not addressed the challenge presented by ovarian cancer. Although the peritoneum is an "accessible" locus for this disease there has been limited characterization of the...
3.
Goldman N, Chandra A, Johnson I, Sullivan M, Patil A, Vanderbeck A, et al.
Nat Immunol
. 2023 Aug;
24(10):1698-1710.
PMID: 37592014
In development, pioneer transcription factors access silent chromatin to reveal lineage-specific gene programs. The structured DNA-binding domains of pioneer factors have been well characterized, but whether and how intrinsically disordered...
4.
Chandra A, Yoon S, Michieletto M, Goldman N, Ferrari E, Abedi M, et al.
Immunity
. 2023 Jun;
56(7):1451-1467.e12.
PMID: 37263273
Multi-enhancer hubs are spatial clusters of enhancers present across numerous developmental programs. Here, we studied the functional relevance of these three-dimensional structures in T cell biology. Mathematical modeling identified a...
5.
TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors
Wang W, Chandra A, Goldman N, Yoon S, Ferrari E, Nguyen S, et al.
Nat Immunol
. 2022 Jun;
23(7):1052-1062.
PMID: 35726060
The high mobility group (HMG) transcription factor TCF-1 is essential for early T cell development. Although in vitro biochemical assays suggest that HMG proteins can serve as architectural elements in...
6.
Fasolino M, Schwartz G, Patil A, Mongia A, Golson M, Wang Y, et al.
Nat Metab
. 2022 Mar;
4(2):284-299.
PMID: 35228745
Type 1 diabetes (T1D) is an autoimmune disease in which immune cells destroy insulin-producing beta cells. The aetiology of this complex disease is dependent on the interplay of multiple heterogeneous...
7.
Londregan J, Maslanka J, Goldman N, Somerville J, Riggs J
Immunobiology
. 2022 Jan;
227(2):152181.
PMID: 35077917
Atypical cytokine production and immune cell subset ratios, particularly those that include high proportions of macrophages, characterize tumor microenvironments (TMEs). TMEs can be modeled by culturing peritoneal cavity (PerC) cells...
8.
Goldman N, Chandra A, Vahedi G
Trends Immunol
. 2021 Nov;
42(12):1060-1062.
PMID: 34772620
There is paucity of information about DNA methylation dynamics in immune cells. Roy et al. mapped the DNA methylation status of several thousand differentially methylated CpGs in human immune cells....
9.
Chandra A, Goldman N, Vahedi G
Immunity
. 2020 Nov;
53(5):895-897.
PMID: 33207211
Understanding the mechanisms that establish regulatory T (Treg) cell identity is central to understanding Treg cell function. van der Veeken et al. now show that the lineage-determining transcription factor Foxp3...
10.
Wang W, Fasolino M, Cattau B, Goldman N, Kong W, Frederick M, et al.
Proc Natl Acad Sci U S A
. 2020 Feb;
117(10):5442-5452.
PMID: 32094195
Chimeric antigen receptor (CAR)-T immunotherapy has yielded impressive results in several B cell malignancies, establishing itself as a powerful means to redirect the natural properties of T lymphocytes. In this...