Najia Jin
Overview
Explore the profile of Najia Jin including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
123
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0
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Recent Articles
1.
Jin N, Matter W, Michael L, Qian Y, Gheyi T, Cano L, et al.
ACS Chem Biol
. 2021 Mar;
16(3):457-462.
PMID: 33656326
Lipoprotein lipase (LPL) is the key enzyme that hydrolyzes triglycerides from triglyceride-rich lipoproteins. Angiopoietin-like proteins (ANGPTL) 3, 4, and 8 are well-characterized protein inhibitors of LPL. ANGPTL8 forms a complex...
2.
Estridge T, Dey A, Reidy C, Yu X, Zhang Y, Hartley M, et al.
J Pharmacol Exp Ther
. 2017 May;
362(1):108-118.
PMID: 28465372
LY2584702 is an inhibitor of p70 S6 kinase-1 previously developed for the treatment of cancer. In two phase 1 trials in oncology patients, significant reductions of total cholesterol, low-density lipoprotein...
3.
Chavali B, Masquelin T, Nilges M, Timm D, Stout S, Matter W, et al.
Appl Magn Reson
. 2015 Jul;
46(8):853-873.
PMID: 26224994
As an early visitor to the injured loci, neutrophil-derived human Myeloperoxidase (hMPO) offers an attractive protein target to modulate the inflammation of the host tissue through suitable inhibitors. We describe...
4.
Braz J, Gill R, Corbly A, Jones B, Jin N, Vlahos C, et al.
Eur J Heart Fail
. 2009 Jul;
11(8):739-48.
PMID: 19633101
Aims: Activation of phosphoinositide-3 kinase (PI3K) is essential for cell growth, relating to adaptive and maladaptive cardiac hypertrophy. This longitudinal canine study was designed to investigate the role of PI3Kalpha...
5.
Gill R, Braz J, Jin N, Etgen G, Shen W
Am J Physiol Heart Circ Physiol
. 2007 Feb;
292(6):H2782-90.
PMID: 17322419
In congestive heart failure (CHF), coronary vascular relaxation is associated with endothelial dysfunction and nitric oxide (NO) deficiency. This study explored the reversibility of this process in hearts recovering from...
6.
Shen W, Spindler M, Higgins M, Jin N, Gill R, Bloem L, et al.
J Mol Cell Cardiol
. 2005 Jun;
39(3):537-44.
PMID: 15978613
Decreases in total creatine kinase (CK) activity and creatine [Cr] combine to limit the capacity of the failing heart to rapidly re-synthesize ATP (energy reserve). If the loss in energy...
7.
Wang X, Mader M, Toth J, Yu X, Jin N, Campbell R, et al.
J Biol Chem
. 2005 Mar;
280(19):19298-305.
PMID: 15737997
Mixed lineage kinase 7 (MLK7) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates the pro-apoptotic signaling pathways p38 and JNK. A library of potential kinase inhibitors was screened,...
8.
Christe M, Jin N, Wang X, Gould K, Iversen P, Yu X, et al.
J Mol Cell Cardiol
. 2004 Sep;
37(3):705-15.
PMID: 15350844
Mixed lineage kinase 7 (MLK7) is a recently identified mitogen-activated protein kinase kinase kinase with enriched expression in skeletal muscle and heart. When over-expressed in cardiac myocytes, MLK7 activates both...
9.
Wang Z, Lanner M, Jin N, Swartz D, Li L, Rhoades R
Am J Respir Cell Mol Biol
. 2003 Apr;
29(4):465-71.
PMID: 12714374
Rho-kinase was recently found to phosphorylate the myosin-binding subunit (MBS) of myosin phosphatase (MP) and to regulate MP activity. Although myosin light chain (MLC) phosphorylation in pulmonary arterial smooth muscle...