Naiduwadura Ivon Upekala De Silva
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Explore the profile of Naiduwadura Ivon Upekala De Silva including associated specialties, affiliations and a list of published articles.
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6
Citations
15
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Recent Articles
1.
Controlled by disorder: Phosphorylation modulates SRSF1 domain availability for spliceosome assembly
Fargason T, Powell E, De Silva N, Paul T, Zhang Z, Prevelige P, et al.
Protein Sci
. 2025 Feb;
34(3):e70070.
PMID: 39968932
Serine/arginine-rich splicing factor 1 (SRSF1) is key in the mRNA lifecycle including transcription, splicing, nonsense-mediated decay, and nuclear export. Consequently, its dysfunction is linked to cancers, viral evasion, and developmental...
2.
Paul T, Zhang P, Zhang Z, Fargason T, De Silva N, Powell E, et al.
Protein Sci
. 2024 Jul;
33(8):e5117.
PMID: 39023093
In eukaryotes, pre-mRNA splicing is vital for RNA processing and orchestrated by the spliceosome, whose assembly starts with the interaction between U1-70K and SR proteins. Despite the significance of the...
3.
De Silva N, Lehman N, Fargason T, Paul T, Zhang Z, Zhang J
Nucleic Acids Res
. 2024 Apr;
52(8):4676-4690.
PMID: 38567732
SRSF1 governs splicing of over 1500 mRNA transcripts. SRSF1 contains two RNA-recognition motifs (RRMs) and a C-terminal Arg/Ser-rich region (RS). It has been thought that SRSF1 RRMs exclusively recognize single-stranded...
4.
De Silva N, Lehman N, Fargason T, Paul T, Zhang Z, Zhang J
bioRxiv
. 2023 Nov;
PMID: 37961538
SRSF1 governs splicing of over 1,500 mRNA transcripts. SRSF1 contains two RNA-recognition motifs (RRMs) and a C-terminal Arg/Ser-rich region (RS). It has been thought that SRSF1 RRMs exclusively recognize single-stranded...
5.
Fargason T, De Silva N, Powell E, Zhang Z, Paul T, Shariq J, et al.
Elife
. 2023 Mar;
12.
PMID: 36862748
Phase separation plays crucial roles in both sustaining cellular function and perpetuating disease states. Despite extensive studies, our understanding of this process is hindered by low solubility of phase-separating proteins....
6.
De Silva N, Fargason T, Zhang Z, Wang T, Zhang J
Biochemistry
. 2022 Dec;
61(24):2922-2932.
PMID: 36454680
Ser/Arg-rich splicing factor 1 (SRSF1 or ASF/SF2) is the prototypical member of SR proteins. SRSF1 binds to exonic splicing enhancers, which prompts inclusion of corresponding exons in the mature mRNA....
7.
Fargason T, Wang T, De Silva N, Zhang Z, McKelvey H, Knapp T, et al.
J Biomol NMR
. 2020 Feb;
74(2-3):119-124.
PMID: 32056065
Residual dipolar couplings (RDCs) provide valuable NMR parameters that can be used for structural calculation and verification. Measuring RDCs requires aligning macromolecules using one of various types of alignment media....