Nagham Alouche
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Explore the profile of Nagham Alouche including associated specialties, affiliations and a list of published articles.
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10
Citations
70
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Recent Articles
1.
Allman A, Gaudette B, Kelly S, Alouche N, Carrington L, Perkey E, et al.
Immunity
. 2024 Dec;
58(1):143-161.e8.
PMID: 39731910
Innate-like splenic marginal zone (MZ) B (MZB) cells play unique roles in immunity due to their rapid responsiveness to blood-borne microbes. How MZB cells integrate cell-extrinsic and -intrinsic processes to...
2.
Eslami M, Schuepbach-Mallepell S, Diana D, Willen L, Kowalczyk-Quintas C, Desponds C, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2404309121.
PMID: 38990948
Antibody-producing plasma cells fuel humoral immune responses. They also contribute to autoimmune diseases such as systemic lupus erythematosus or IgA nephropathy. Interleukin-6 and the tumor necrosis factor (TNF) family ligands...
3.
Marin-Esteban V, Molet L, Lagana M, Ciocan D, Dominguez-Lafage C, Alouche N, et al.
N Engl J Med
. 2024 Apr;
390(14):1339-1341.
PMID: 38598804
No abstract available.
4.
Juilland M, Alouche N, Ubezzi I, Gonzalez M, Rashid H, Scarpellino L, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(52):e2301155120.
PMID: 38109544
The protease MALT1 promotes lymphocyte activation and lymphomagenesis by cleaving a limited set of cellular substrates, most of which control gene expression. Here, we identified the integrin-binding scaffold protein Tensin-3...
5.
Bonaud A, Gargowitsch L, Gilbert S, Rajan E, Canales-Herrerias P, Stockholm D, et al.
Proc Natl Acad Sci U S A
. 2023 Jan;
120(2):e2213056120.
PMID: 36595686
Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the soluble N-ethylmaleimide-sensitive...
6.
Houde N, Beuret L, Bonaud A, Fortier-Beaulieu S, Truchon-Landry K, Aoidi R, et al.
Cell Rep
. 2022 Jan;
38(2):110223.
PMID: 35021072
MEK1 and MEK2, the only known activators of ERK, are attractive therapeutic candidates for both cancer and autoimmune diseases. However, how MEK signaling finely regulates immune cell activation is only...
7.
Alouche N, Bonaud A, Rondeau V, Hussein-Agha R, Nguyen J, Bisio V, et al.
Blood
. 2021 Jan;
137(22):3050-3063.
PMID: 33512437
The extrafollicular immune response is essential to generate a rapid but transient wave of protective antibodies during infection. Despite its importance, the molecular mechanisms controlling this first response are poorly...
8.
Aparicio-Domingo P, Cannelle H, Buechler M, Nguyen S, Kallert S, Favre S, et al.
Eur J Immunol
. 2020 Jul;
51(1):76-90.
PMID: 32700362
Upon viral infection, stressed or damaged cells can release alarmins like IL-33 that act as endogenous danger signals alerting innate and adaptive immune cells. IL-33 coming from nonhematopoietic cells has...
9.
Espeli M, Bashford-Rogers R, Sowerby J, Alouche N, Wong L, Denton A, et al.
Nat Commun
. 2019 May;
10(1):1970.
PMID: 31036800
Several tolerance checkpoints exist throughout B cell development to control autoreactive B cells and prevent the generation of pathogenic autoantibodies. FcγRIIb is an Fc receptor that inhibits B cell activation...
10.
Biajoux V, Natt J, Freitas C, Alouche N, Sacquin A, Hemon P, et al.
Cell Rep
. 2016 Sep;
17(1):193-205.
PMID: 27681431
CXCR4 plays a central role in B cell immune response, notably by promoting plasma cell (PC) migration and maintenance in the bone marrow (BM). Gain-of-function mutations in CXCR4 affecting receptor...