Nagakumar Bharatham
Overview
Explore the profile of Nagakumar Bharatham including associated specialties, affiliations and a list of published articles.
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30
Citations
342
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Recent Articles
1.
Hameed P S, Kotakonda H, Sharma S, Nandishaiah R, Katagihallimath N, Rao R, et al.
Nat Commun
. 2025 Feb;
16(1):2082.
PMID: 40021680
No abstract available.
2.
Hameed P S, Kotakonda H, Sharma S, Nandishaiah R, Katagihallimath N, Rao R, et al.
Nat Commun
. 2025 Jan;
16(1):625.
PMID: 39805821
No abstract available.
3.
Hameed P S, Kotakonda H, Sharma S, Nandishaiah R, Katagihallimath N, Rao R, et al.
Nat Commun
. 2024 Sep;
15(1):8202.
PMID: 39294149
The global crisis of antimicrobial resistance (AMR) necessitates the development of broad-spectrum antibacterial drugs effective against multi-drug resistant (MDR) pathogens. BWC0977, a Novel Bacterial Topoisomerase Inhibitor (NBTI) selectively inhibits bacterial...
4.
Bhowmik P, Bharatham N, Murakami S, Ramachandran V, Datta S
Res Microbiol
. 2023 Feb;
174(4):104039.
PMID: 36738814
OqxB belongs to the RND (Resistance-Nodulation-Division) efflux pump family, recognized widely as a major contributor towards enhancing antimicrobial resistance. It is known to be predominantly present in all Klebsiella spp....
5.
Math R, Bharatham N, Javaregowda P, Yun H
Appl Microsc
. 2021 Nov;
51(1):17.
PMID: 34762191
Our previous study on the binding activity between Cel5H and clay minerals showed highest binding efficiency among other cellulase enzymes cloned. Here, based on previous studies, we hypothesized that the...
6.
Sharma S, Rao R, Reeve S, Phelps G, Bharatham N, Katagihallimath N, et al.
ACS Infect Dis
. 2021 Oct;
7(11):3009-3024.
PMID: 34699190
We discovered azaindole-based compounds with weak innate activity that exhibit substantial potentiation of antibacterial activities of different antibiotics, viz., rifampicin, erythromycin, solithromycin, and novobiocin in Gram-negative bacteria. In the presence...
7.
Bharatham N, Bhowmik P, Aoki M, Okada U, Sharma S, Yamashita E, et al.
Nat Commun
. 2021 Sep;
12(1):5400.
PMID: 34518546
OqxB is an RND (Resistance-Nodulation-Division) efflux pump that has emerged as a factor contributing to the antibiotic resistance in Klebsiella pneumoniae. OqxB underwent horizontal gene transfer and is now seen...
8.
Lang Y, Shah N, Tao X, Reeve S, Zhou J, Moya B, et al.
Clin Pharmacol Ther
. 2021 Feb;
109(4):1000-1020.
PMID: 33576025
Multidrug-resistant bacteria are causing a serious global health crisis. A dramatic decline in antibiotic discovery and development investment by pharmaceutical industry over the last decades has slowed the adoption of...
9.
Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer
Slavish P, Chi L, Yun M, Tsurkan L, Martinez N, Jonchere B, et al.
Cancer Res
. 2020 Jul;
80(17):3507-3518.
PMID: 32651255
Inhibition of members of the bromodomain and extraterminal (BET) family of proteins has proven a valid strategy for cancer chemotherapy. All BET identified to date contain two bromodomains (BD; BD1...
10.
Haq S, Shanbhag A, Karthikeyan S, Hassan I, Thanukrishnan K, Ashok A, et al.
Microb Cell Fact
. 2018 Dec;
17(1):192.
PMID: 30509260
Introduction: Chemical industries are constantly in search of an expeditious and environmentally benign method for producing chiral synthons. Ketoreductases have been used as catalysts for enantioselective conversion of desired prochiral...