Nadine D van Kleef
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Explore the profile of Nadine D van Kleef including associated specialties, affiliations and a list of published articles.
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9
Citations
104
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Recent Articles
1.
Raaphorst H, Lougheed S, Saou L, van Kleef N, Rensink I, Ten Brinke A, et al.
Immunol Cell Biol
. 2024 Dec;
103(2):178-191.
PMID: 39740009
Understanding antigen-specific T-cell responses is crucial for advancing immunotherapies and vaccine development. This study proposes a novel approach combining two complementary assays: the 5-ethynyl-2'-deoxyuridine (EdU) incorporation assay (tracking proliferation over...
2.
Lischer C, Eberhardt M, Flamann C, Berges J, Guse E, Wessely A, et al.
J Immunother Cancer
. 2024 May;
12(5).
PMID: 38724462
Background: Tumor-associated antigens and their derived peptides constitute an opportunity to design off-the-shelf mainline or adjuvant anti-cancer immunotherapies for a broad array of patients. A performant and rational antigen selection...
3.
Cruz M, Bohinc D, Andraska E, Alvikas J, Raghunathan S, Masters N, et al.
Nat Nanotechnol
. 2022 Jul;
17(9):1004-1014.
PMID: 35851383
Targeted drug delivery to disease-associated activated neutrophils can provide novel therapeutic opportunities while avoiding systemic effects on immune functions. We created a nanomedicine platform that uniquely utilizes an α-antitrypsin-derived peptide...
4.
de Vries J, Visser C, Geers L, Slotman J, van Kleef N, Maas C, et al.
J Thromb Haemost
. 2022 Mar;
20(6):1412-1420.
PMID: 35316570
Background: Severe acute respiratory syndrome coronavirus 2 infection is associated with an increased incidence of thrombosis. Objectives: By studying the fibrin network structure of coronavirus disease 2019 (COVID-19) patients, we...
5.
van Moorsel M, Poolen G, Koekman C, Verhoef S, de Maat S, Barendrecht A, et al.
J Thromb Haemost
. 2022 Feb;
20(5):1213-1222.
PMID: 35170225
Background: Thrombomodulin on endothelial cells can form a complex with thrombin. This complex has both anticoagulant properties, by activating protein C, and clot-protective properties, by activating thrombin-activatable fibrinolysis inhibitor (TAFI)....
6.
Sprenkeler E, Zandstra J, van Kleef N, Goetschalckx I, Verstegen B, Aarts C, et al.
Cells
. 2022 Jan;
11(2).
PMID: 35053354
Neutrophils are the most abundant innate immune cells in the circulation and they are the first cells recruited to sites of infection or inflammation. Almost half of the intracellular protein...
7.
de Maat S, Clark C, Barendrecht A, Smits S, van Kleef N, El Otmani H, et al.
Blood
. 2021 Nov;
139(4):597-607.
PMID: 34752601
Thrombotic microangiopathies are hallmarked by attacks of disseminated microvascular thrombosis. In thrombotic thrombocytopenic purpura (TTP), this is caused by a rise in thrombogenic ultra-large von Willebrand factor (VWF) multimers because...
8.
Sanrattana W, Sefiane T, Smits S, van Kleef N, Fens M, Lenting P, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(45).
PMID: 34740972
Serine proteases are essential for many physiological processes and require tight regulation by serine protease inhibitors (SERPINs). A disturbed SERPIN-protease balance may result in disease. The reactive center loop (RCL)...
9.
Sanrattana W, Smits S, Barendrecht A, van Kleef N, El Otmani H, Zivkovic M, et al.
J Thromb Haemost
. 2021 Oct;
20(2):353-365.
PMID: 34653316
Background: Occlusive thrombi are not homogeneous in composition. The core of a thrombus is rich in activated platelets and fibrin while the outer shell contains resting platelets. This core is...