Alpha 2.0
Login Register
» Authors » Nadia Hanafy Metwally

Nadia Hanafy Metwally

Explore the profile of Nadia Hanafy Metwally including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 14
Citations 75
Followers 0
Related Specialties
Chemistry
Biochemistry
Science
Top 10 Co-Authors
Ibrahim Taha Radwan
Galal Hamza Elgemeie
Ibrahim M El-Sherbiny
Mona Said Mohamed
Ebrahim Adel El-Desoky
Salwa Magdy Eldaly
Magda Ahmed Abdalla
Mohamed Ahmed Mohamed
Emad Abdallah Deeb
Marwa Maher Abdel Mohsen
Published In
Bioorg Chem
BMC Chem
ACS Omega
Sci Rep
Carbohydr Res
Affiliations
Soon will be listed here.
Recent Articles
1.
Synthesis, antibacterial evaluation and in silico studies of novel 2-(benzo[d]thiazol-2-yl)-N-arylacetamides and their derivatives as potential DHFR inhibitors
Metwally N, Elgemeie G, Abdelrazek A, Eldaly S
BMC Chem . 2025 Jan; 19(1):29. PMID: 39891220
Novel N-arylacetamides 2a-f were synthesized based on benzo[d]thiazole scaffold. The compounds 2a-c underwent Knoevenagel condensation through green synthetic method with different aromatic aldehydes and pyrazole-7-carbaldehydes delivered the respective arylidenes with...
2.
Design, synthesis of some novel coumarins and their nanoformulations into lipid-chitosan nanocapsule as unique antimicrobial agents
Radwan I, El-Sherbiny I, Selim A, Metwally N
Sci Rep . 2024 Dec; 14(1):30598. PMID: 39715779
Developing and creating novel antibiotics is one of the most important targets in treating infectious diseases. Novel coumarins were synthesized and characterized using different spectroscopic techniques such as Fourier Transform...
3.
Synergistic and potential antifungal properties of tailored, one pot multicomponent monoterpenes co-delivered with fluconazole encapsulated nanostructure lipid carrier
Radwan I, El-Sherbiny I, Metwally N
Sci Rep . 2024 Jun; 14(1):14382. PMID: 38909063
Frequent and variant infections are caused by the virtue of opportunistic fungi pathogens. Candidiasis, aspergillosis, and mucormycosis are pathogenic microorganisms that give rise to vast fungal diseases that alternate between...
4.
Synthesis, anticancer evaluation, molecular docking and ADME study of novel pyrido[4',3':3,4]pyrazolo[1,5-a]pyrimidines as potential tropomyosin receptor kinase A (TrKA) inhibitors
Metwally N, Deeb E, Hasani I
BMC Chem . 2024 Apr; 18(1):68. PMID: 38582910
The starting compound 3-amino-1,7-dihydro-4H-pyrazolo[4,3-c]pyridine-4,6(5H)-dione (1) is reacted with each of diketone and β-ketoester, forming pyridopyrazolo[1,5-a]pyrimidines 4a,b and 14a,b, respectively. The compounds 4 and 14 reacted with each of aromatic aldehyde...
5.
Synthesis and Biological Evaluation of Benzothiazolyl-pyridine Hybrids as New Antiviral Agents against H5N1 Bird Flu and SARS-COV-2 Viruses
Metwally N, Elgemeie G, Fahmy F
ACS Omega . 2023 Oct; 8(40):36636-36654. PMID: 37841136
A novel series of benzothiazolyl-pyridine hybrids - and - were produced from the reaction of enamine derivative with each of the arylcyanoacetamides - and cyanoacetohydrazides -. The new products were...
6.
Design, Synthesis, Anticancer Evaluation and Molecular Modeling Studies of New Thiazolidinone-Benzoate Scaffold as EGFR Inhibitors, Cell Cycle Interruption and Apoptosis Inducers in HepG2
Eldaly S, Salama Zakaria D, Metwally N
Chem Biodivers . 2023 Sep; 20(10):e202300138. PMID: 37695095
Synthesis of new anticancer candidates with protein kinases inhibitory potency is a major goal of pharmaceutical science and synthetic research. This current work represents the synthesis of a series of...
7.
Novel Thiopyrano[2,3-]thiazole-pyrazole Hybrids as Potential Nonsulfonamide Human Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, and Biochemical Studies
Metwally N, El-Desoky E
ACS Omega . 2023 Feb; 8(6):5571-5592. PMID: 36816682
In recent years, molecular hybridization strategies have developed into a potent strategy for drug discovery. A series of novel thiopyrano[2,3-]thiazoles linked to the pyrazole moiety was designed and developed as...
8.
Design, green one-pot synthesis and molecular docking study of novel N,N-bis(cyanoacetyl)hydrazines and bis-coumarins as effective inhibitors of DNA gyrase and topoisomerase IV
Metwally N, Abdallah S, Mohsen M
Bioorg Chem . 2020 Mar; 97:103672. PMID: 32145481
A novel, quick, environmentally safe, and one-pot synthesis of a series of N,N-bis(cyanoacetyl)hydrazine derivatives, bis-imino-2H-chromenes and bis-2-oxo-2H-chromene derivatives have been designed. Some selected newly synthesized compounds were investigated in vitro...
9.
New imidazolone derivatives comprising a benzoate or sulfonamide moiety as anti-inflammatory and antibacterial inhibitors: Design, synthesis, selective COX-2, DHFR and molecular-modeling study
Metwally N, Mohamed M
Bioorg Chem . 2019 Dec; 99:103438. PMID: 31796216
New imidazol-5-one derivatives 12a,b and 12e, f, 14a,b and 16a,b were synthesized and screened for their in vivo anti-inflammatory activity using a standard acute carrageenan-induced rat paw oedema method. All...
10.
Grafting of multiwalled carbon nanotubes with pyrazole derivatives: characterization, antimicrobial activity and molecular docking study
Metwally N, Saad G, Abd El-Wahab E
Int J Nanomedicine . 2019 Nov; 14:6645-6659. PMID: 31686804
Introduction: It is well known that the grafted multiwalled carbon nanotubes (MWCNTs) have antibacterial activity and lower cytotoxicity. Moreover, pyrazole derivatives have a broad spectrum of biological activity due to...