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N Tokuriki

Explore the profile of N Tokuriki including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
Citations 85
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Recent Articles
1.
Chen J, Bisardi M, Lee D, Cotogno S, Zamponi F, Weigt M, et al.
Nat Commun . 2024 Nov; 15(1):10276. PMID: 39604374
No abstract available.
2.
Chen J, Bisardi M, Lee D, Cotogno S, Zamponi F, Weigt M, et al.
Nat Commun . 2024 Sep; 15(1):8441. PMID: 39349467
Throughout evolution, protein families undergo substantial sequence divergence while preserving structure and function. Although most mutations are deleterious, evolution can explore sequence space via epistatic networks of intramolecular interactions that...
3.
Chen J, Fowler D, Tokuriki N
Nat Ecol Evol . 2022 Feb; 6(4):427-438. PMID: 35210579
Fitness landscapes, mappings of genotype/phenotype to their effects on fitness, are invaluable concepts in evolutionary biochemistry. Although widely discussed, measurements of phenotype-fitness landscapes in proteins remain scarce. Here, we quantify...
4.
Baier F, Copp J, Tokuriki N
Biochemistry . 2016 Nov; 55(46):6375-6388. PMID: 27802036
The sequence and functional diversity of enzyme superfamilies have expanded through billions of years of evolution from a common ancestor. Understanding how protein sequence and functional "space" have expanded, at...
5.
Jackson C, Foo J, Tokuriki N, Afriat L, Carr P, Kim H, et al.
Proc Natl Acad Sci U S A . 2009 Dec; 106(51):21631-6. PMID: 19966226
To efficiently catalyze a chemical reaction, enzymes are required to maintain fast rates for formation of the Michaelis complex, the chemical reaction and product release. These distinct demands could be...
6.
Tokuriki N, Sakamoto K, Waluyo D, Makino Y, Ogasahara K, Yutani K, et al.
J Biosci Bioeng . 2005 Oct; 92(2):167-72. PMID: 16233078
Physicochemical properties of four random proteins, each consisting of about 150 amino acid residues with different sequence identity, were compared to know the correlation between the physicochemical properties and its...