N Lehming
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Explore the profile of N Lehming including associated specialties, affiliations and a list of published articles.
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17
Citations
466
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Recent Articles
1.
Kerkmann K, Lehming N
Curr Genet
. 2001 Aug;
39(5-6):284-90.
PMID: 11525400
Tuplp is a general corepressor in Saccharomyces cerevisiae. We performed a split-ubiquitin screen with Tup1p as bait, in order to understand how Tuplp mediates repression. Cdc73p was the only component...
2.
Patzold A, Lehming N
FEBS Lett
. 2001 Apr;
494(1-2):64-8.
PMID: 11297736
Upon uracil depletion, the transcriptional activator Ppr1p stimulates expression of the Saccharomyces cerevisiae URA3 gene only four-fold. We performed a split-ubiquitin screen with Tup1p as bait, and we found that...
3.
Gromoller A, Lehming N
EMBO J
. 2000 Dec;
19(24):6845-52.
PMID: 11118219
The holoenzyme of transcription integrates the positive and negative signals from the promoters of eukaryotic genes. We demonstrate that the essential holoenzyme component Srb7p is a physiologically relevant target of...
4.
Laser H, Bongards C, Schuller J, Heck S, Johnsson N, Lehming N
Proc Natl Acad Sci U S A
. 2000 Nov;
97(25):13732-7.
PMID: 11095729
The split-ubiquitin assay detects protein interactions in vivo. To identify proteins interacting with Gal4p and Tup1p, two transcriptional regulators, we converted the split-ubiquitin assay into a generally applicable screen for...
5.
Gromoller A, Lehming N
FEBS Lett
. 2000 Nov;
484(1):48-54.
PMID: 11056220
The mediator complex in the RNA polymerase II holoenzyme is known to be involved in transcriptional activation. The role of the essential mediator component Srb7p has been difficult to investigate,...
6.
Morley D, Heck S, Lehming N
Biochem J
. 2000 Jun;
348 Pt 3:585-90.
PMID: 10839990
In the present study we present a new method that allows for the selection of protein interactions in mammalian cells. We have used this system to verify two interactions previously...
7.
Wellhausen A, Lehming N
FEBS Lett
. 1999 Jul;
453(3):299-304.
PMID: 10405164
The artificial basic repressor SSB24 represses transcription of a reporter construct activated by GCN4. We show that the positively charged SSB24 and the negatively charged acidic activator GCN4 interact in...
8.
Lehming N, Le Saux A, Schuller J, Ptashne M
Proc Natl Acad Sci U S A
. 1998 Jun;
95(13):7322-6.
PMID: 9636147
The Drosophila HMG1-like protein DSP1 was identified by its ability to inhibit the transcriptional activating function of Dorsal in a promoter-specific fashion in yeast. We show here that DSP1 as...
9.
Lehming N, McGuire S, Brickman J, Ptashne M
Proc Natl Acad Sci U S A
. 1995 Oct;
92(22):10242-6.
PMID: 7479760
Cactus, a Drosophila homologue of I kappa B, binds to and inhibits Dorsal, a homologue of the p50 and p65 components of NF-kappa B. We describe experiments in yeast with...
10.
Lehming N, Thanos D, Brickman J, Ma J, Maniatis T, Ptashne M
Nature
. 1994 Sep;
371(6493):175-9.
PMID: 8072548
One protein can activate some genes and repress others in the same cell. The Drosophila protein Dorsal (which, like the human protein NF-kappa B3, is a member of the Rel...