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N L Kruhlak

Explore the profile of N L Kruhlak including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 3
Citations 30
Followers 0
Related Specialties
Pharmacology
Toxicology
Chemistry
Top 10 Co-Authors
R D Benz
M Wang
X Han
J F Rathman
S Boyer
T J Colatsky
P Dierkes
P M Boorman
R Benigni
J Jaworska
Published In
Inorg Chem
Toxicol Mech Methods
Clin Pharmacol Ther
Affiliations
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Recent Articles
1.
(Q)SAR modeling and safety assessment in regulatory review
Kruhlak N, Benz R, Zhou H, Colatsky T
Clin Pharmacol Ther . 2012 Jan; 91(3):529-34. PMID: 22258468
The ability to predict clinical safety based on chemical structures is becoming an increasingly important part of regulatory decision making. (Quantitative) structure-activity relationship ((Q)SAR) models are currently used to evaluate...
2.
Understanding genetic toxicity through data mining: the process of building knowledge by integrating multiple genetic toxicity databases
Yang C, Hasselgren C, Boyer S, Arvidson K, Aveston S, Dierkes P, et al.
Toxicol Mech Methods . 2009 Dec; 18(2-3):277-95. PMID: 20020921
ABSTRACT Genetic toxicity data from various sources were integrated into a rigorously designed database using the ToxML schema. The public database sources include the U.S. Food and Drug Administration (FDA)...
3.
Syntheses, structures, and stabilities of [PPh(4)][WS(3)(SR)](R=(i)Bu,(i)Pr,(i)Bu, benzyl, allyl) and [PPh(4)][MoS(3)(S(t)Bu)]
Kruhlak N, Wang M, Boorman P, Parvez M, McDonald R
Inorg Chem . 2001 Jun; 40(13):3141-8. PMID: 11399185
Intermediates in the condensation process of [MS(4)](2)(-) (M = Mo, W) to polythiometalates, in the presence of alkyl halides, had not been reported prior to our communication of [PPh(4)][WS(3)(SEt)] (Boorman,...