N El Tayar
Overview
Explore the profile of N El Tayar including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
216
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Recent Articles
1.
El Tayar N, Karajiannis H, van de Waterbeemd H
Amino Acids
. 2013 Nov;
8(2):125-39.
PMID: 24186323
Understanding the physicochemical and structural properties of peptides are important prerequisites for the rational design of bioactive peptides and peptidomimetics. The present contribution reviews methods used for the assessment and...
2.
van de Waterbeemd H, Karajiannis H, El Tayar N
Amino Acids
. 2013 Nov;
7(2):129-45.
PMID: 24186046
The lipophilicity (or hydrophobicity) of amino acids is an important property relevant for protein folding and therefore of great interest in protein engineering. For peptides or peptidomimetics of potential therapeutic...
3.
El Tayar N
Mol Cell Endocrinol
. 1996 Dec;
125(1-2):65-70.
PMID: 9027344
The extracellular domain (ECD) of gonadotropin receptors belong to the leucine-rich repeat (LRR) protein superfamily and their transmembrane domain (TMD) is characteristic of the seven alpha-helices G-protein-coupled receptors (GPCR). The...
4.
Jiang X, Dreano M, Buckler D, Cheng S, Ythier A, Wu H, et al.
Structure
. 1995 Dec;
3(12):1341-53.
PMID: 8747461
Background: Glycoprotein hormones influence the development and function of the ovary, testis and thyroid by binding to specific high-affinity receptors. The extracellular domains of these receptors are members of the...
5.
El Tayar N, Mark A, Vallat P, Brunne R, Testa B, van Gunsteren W
J Med Chem
. 1993 Nov;
36(24):3757-64.
PMID: 8254605
The partition coefficient of cyclosporin A (CsA) was measured in octanol/water and heptane/water by centrifugal partition chromatography. By comparison with results from model compounds, it was deduced that the hydrogen-bonding...
6.
Tsai R, Carrupt P, Testa B, Gaillard P, El Tayar N, Hogberg T
J Med Chem
. 1993 Jan;
36(2):196-204.
PMID: 8423592
Previous work has shown that raclopride in water at neutral pH exists in a zwitterionic form, suggesting a stereoelectronic structure largely different from that of other benzamides. In the present...
7.
Altomare C, Carrupt P, Gaillard P, El Tayar N, Testa B, Carotti A
Chem Res Toxicol
. 1992 May;
5(3):366-75.
PMID: 1504260
The 1-octanol/water partition coefficients of a number of toxic and nontoxic analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were determined using centrifugal partition chromatography (CPC), a novel and effective technique for measuring lipophilicity,...
8.
El Tayar N, Tsai R, Testa B, Carrupt P, HANSCH C, Leo A
J Pharm Sci
. 1991 Aug;
80(8):744-9.
PMID: 1791533
Human skin permeation data taken from the literature were analyzed for quantitative relationships with physicochemical properties and structural descriptors. No correlations exist with molecular weights and solvent-accessible surface areas. In...
9.
El Tayar N, Tsai R, Testa B, Carrupt P, Leo A
J Pharm Sci
. 1991 Jun;
80(6):590-8.
PMID: 1941553
Published partition coefficient values of 121 solutes in five solvent systems (1-octanol-water, n-heptane-water, chloroform-water, diethyl ether-water, and n-butyl acetate-water) were correlated with solute properties, namely intrinsic molecular volume (indicator of...
10.
Carrupt P, Testa B, Bechalany A, El Tayar N, Descas P, Perrissoud D
J Med Chem
. 1991 Apr;
34(4):1272-5.
PMID: 2016703
Morphine 6-glucuronide, but not morphine 3-glucuronide, is a highly potent opiate receptor agonist. In fact, there is converging evidence that much of the analgesic effect occurring after morphine treatment in...