My-Hue Le
Overview
Explore the profile of My-Hue Le including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
28
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0
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Recent Articles
1.
Neblik J, Kirupakaran A, Beuck C, Mieres-Perez J, Niemeyer F, Le M, et al.
J Am Chem Soc
. 2023 Jul;
145(28):15251-15264.
PMID: 37392180
Binding of microtubule filaments by the conserved Ndc80 protein is required for kinetochore-microtubule attachments in cells and the successful distribution of the genetic material during cell division. The reversible inhibition...
2.
Weil T, Kirupakaran A, Le M, Rebmann P, Mieres-Perez J, Issmail L, et al.
JACS Au
. 2022 Oct;
2(9):2187-2202.
PMID: 36186568
The COVID-19 pandemic caused by SARS-CoV-2 presents a global health emergency. Therapeutic options against SARS-CoV-2 are still very limited but urgently required. Molecular tweezers are supramolecular agents that destabilize the...
3.
Le M, Taghuo K E, Schrader T
Chem Commun (Camb)
. 2022 Feb;
58(18):2954-2966.
PMID: 35170594
A new supramolecular approach to broad spectrum antivirals utilizes host guest chemistry between molecular tweezers and lysine/arginine as well as choline. Basic amino acids in amyloid-forming SEVI peptides (semen-derived enhancers...
4.
Warmerdam Z, Kamba B, Le M, Schrader T, Isaacs L, Bayer P, et al.
Chembiochem
. 2021 Nov;
23(2):e202100502.
PMID: 34758178
Methylated free amino acids are an important class of targets for host-guest chemistry that have recognition properties distinct from those of methylated peptides and proteins. We present comparative binding studies...
5.
Weil T, Gross R, Rocker A, Bravo-Rodriguez K, Heid C, Sowislok A, et al.
J Am Chem Soc
. 2020 Sep;
142(40):17024-17038.
PMID: 32926779
Broad-spectrum antivirals are powerful weapons against dangerous viruses where no specific therapy exists, as in the case of the ongoing SARS-CoV-2 pandemic. We discovered that a lysine- and arginine-specific supramolecular...