Muneaki Nakamura
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Explore the profile of Muneaki Nakamura including associated specialties, affiliations and a list of published articles.
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12
Citations
791
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Recent Articles
1.
Marsiglia J, Vaalavirta K, Knight E, Nakamura M, Cong L, Hughes N
Cell Rep Methods
. 2024 Oct;
4(10):100882.
PMID: 39437714
The application of CRISPR-Cas systems to genome editing has revolutionized experimental biology and is an emerging gene and cell therapy modality. CRISPR-Cas systems target off-target regions within the human genome,...
2.
Nakamura M, Ivec A, Gao Y, Qi L
Biodes Res
. 2023 Oct;
2021:9815820.
PMID: 37849948
Development of CRISPR-based epigenome editing tools is important for the study and engineering of biological behavior. Here, we describe the design of a reporter system for quantifying the ability of...
3.
Lin X, Liu Y, Liu S, Zhu X, Wu L, Zhu Y, et al.
Science
. 2022 Aug;
377(6610):1077-1085.
PMID: 35951677
Mammalian genomes have multiple enhancers spanning an ultralong distance (>megabases) to modulate important genes, but it is unclear how these enhancers coordinate to achieve this task. We combine multiplexed CRISPRi...
4.
Xu X, Chemparathy A, Zeng L, Kempton H, Shang S, Nakamura M, et al.
Mol Cell
. 2021 Sep;
81(20):4333-4345.e4.
PMID: 34480847
Compact and versatile CRISPR-Cas systems will enable genome engineering applications through high-efficiency delivery in a wide variety of contexts. Here, we create an efficient miniature Cas system (CasMINI) engineered from...
5.
Ruijgrok P, Ghosh R, Zemsky S, Nakamura M, Gong R, Ning L, et al.
Nat Chem Biol
. 2021 Feb;
17(5):540-548.
PMID: 33603247
Precision tools for spatiotemporal control of cytoskeletal motor function are needed to dissect fundamental biological processes ranging from intracellular transport to cell migration and division. Direct optical control of motor...
6.
Nakamura M, Gao Y, Dominguez A, Qi L
Nat Cell Biol
. 2021 Jan;
23(1):11-22.
PMID: 33420494
The epigenome involves a complex set of cellular processes governing genomic activity. Dissecting this complexity necessitates the development of tools capable of specifically manipulating these processes. The repurposing of prokaryotic...
7.
Wang H, Nakamura M, Abbott T, Zhao D, Luo K, Yu C, et al.
Science
. 2019 Sep;
365(6459):1301-1305.
PMID: 31488703
We report a robust, versatile approach called CRISPR live-cell fluorescent in situ hybridization (LiveFISH) using fluorescent oligonucleotides for genome tracking in a broad range of cell types, including primary cells....
8.
Nakamura M, Srinivasan P, Chavez M, Carter M, Dominguez A, La Russa M, et al.
Nat Commun
. 2019 Jan;
10(1):194.
PMID: 30643127
Repurposed CRISPR-Cas molecules provide a useful tool set for broad applications of genomic editing and regulation of gene expression in prokaryotes and eukaryotes. Recent discovery of phage-derived proteins, anti-CRISPRs, which...
9.
Nakamura M, Chen L, Howes S, Schindler T, Nogales E, Bryant Z
Nat Nanotechnol
. 2014 Aug;
9(9):693-7.
PMID: 25086603
Cytoskeletal motors perform critical force generation and transport functions in eukaryotic cells. Engineered modifications of motor function provide direct tests of protein structure-function relationships and potential tools for controlling cellular...
10.
Schindler T, Chen L, Lebel P, Nakamura M, Bryant Z
Nat Nanotechnol
. 2013 Nov;
9(1):33-8.
PMID: 24240432
Cytoskeletal motors act as cargo transporters in cells and may be harnessed for directed transport applications in molecular detection and diagnostic devices. High processivity, the ability to take many steps...