Muhammad Zafarullah
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Explore the profile of Muhammad Zafarullah including associated specialties, affiliations and a list of published articles.
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25
Citations
597
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Recent Articles
1.
Farooq U, Rasul A, Zafarullah M, Abbas G, Rasool M, Ali F, et al.
Des Monomers Polym
. 2021 Aug;
24(1):240-258.
PMID: 34434070
In the current research, attempt is made to fabricate a nanoemulsion (NE) containing an antifungal agent. The prepared formulation has been expected to enhance skin penetration. It is also studied...
2.
Ma A, Jiang L, Song L, Hu Y, Dun H, Daloze P, et al.
Int Immunopharmacol
. 2013 Mar;
16(3):399-408.
PMID: 23499511
Objective: Articular cartilage defects are commonly associated with trauma, inflammation and osteoarthritis. Mesenchymal stem cell (MSC)-based therapy is a promising novel approach for repairing articular cartilage. Direct intra-articular injection of...
3.
Jiang L, Ma A, Song L, Hu Y, Dun H, Daloze P, et al.
J Tissue Eng Regen Med
. 2013 Jan;
8(11):896-905.
PMID: 23335439
Osteoarthritis (OA) is the most common form of arthritis, in which cartilage is irreversibly degraded, causing severe pain and disability. Current therapeutic strategies cannot repair damaged cartilage. We evaluated the...
4.
Sylvester J, El Mabrouk M, Ahmad R, Chaudry A, Zafarullah M
Cell Physiol Biochem
. 2012 Jul;
30(3):563-74.
PMID: 22832115
Background/aims: We investigated the unknown molecular mechanisms of Interleukin-1 (IL-1β)-induced cartilage aggrecan degeneration by aggrecanase (ADAMTS-A Disintegrin And Metalloproteinase with ThromboSpondin motifs) in human articular chondrocytes, a model mimicking human...
5.
Huang W, El Mabrouk M, Sylvester J, Dehnade F, Zafarullah M
Open Rheumatol J
. 2012 Jan;
5:81-7.
PMID: 22216069
Objective: Tissue inhibitors of metalloproteinases (TIMPs) are multi-functional proteins with matrix metalloproteinases-inhibiting activities. We studied expression of anti-inflammatory, TIMP-4 gene in human joint tissues and its regulation by arthritis-associated cytokines....
6.
Sylvester J, Ahmad R, Zafarullah M
Rheumatol Int
. 2011 Nov;
33(2):517-22.
PMID: 22065068
Proinflammatory cytokines such as interleukin-1 beta (IL-1β) stimulate cartilage extracellular matrix aggrecan degradation by aggrecanases or ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) during the pathogenesis of arthritis. Human...
7.
Khalife S, Zafarullah M
Arthritis Res Ther
. 2011 Feb;
13(1):102.
PMID: 21345249
Patients with rheumatoid arthritis (RA) and osteoarthritis (OA) consume 'natural health products' (NHPs) whose therapeutic efficacy, toxicity and mechanisms of action are poorly understood. In a previous issue of Arthritis...
8.
Ahmad R, Sylvester J, Ahmad M, Zafarullah M
Arch Biochem Biophys
. 2011 Jan;
507(2):350-5.
PMID: 21211511
Proinflammatory cytokines such as interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) enhance degradation of cartilage-specific, type II collagen by matrix metalloproteinase-13 (MMP-13). We investigated the previously unknown role...
9.
Ahmad R, Sylvester J, Ahmad M, Zafarullah M
J Immunol
. 2009 Apr;
182(8):5081-7.
PMID: 19342688
Aggrecanases (a disintegrin [corrected] and metalloproteinase with thrombospondin motif, ADAMTSs) are principal proteases involved in cartilage extracellular matrix aggrecan degradation. The role and relative contribution of MyD88, IRAK1, and TRAF6...
10.
Qureshi H, Ahmad R, Zafarullah M
Anal Biochem
. 2008 Aug;
382(2):138-40.
PMID: 18703012
Extracellular matrix (ECM)-rich cartilage-derived chondrocytes are difficult to transfect with DNA/RNA. We modified the classical calcium phosphate transfection method by detaching adherent chondrocytes with trypsin and resuspending in CaPo4-nucleic acid...