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» Authors » Mstislav I Lavrov

Mstislav I Lavrov

Explore the profile of Mstislav I Lavrov including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 34
Followers 0
Related Specialties
Molecular Biology
Biochemistry
Chemistry
Top 10 Co-Authors
Vladimir A Palyulin
Vladimir V Grigoriev
Dmitry S Karlov
Elena A Golubeva
Kseniya N Sedenkova
Tatiana V Vyunova
Elena B Averina
Yuri K Grishin
Vladimir L Zamoyski
Eugene V Radchenko
Published In
J Biomol Struct Dyn
Curr Mol Pharmacol
Int J Mol Sci
Mol Neurobiol
Molecules
Affiliations
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Recent Articles
1.
New Allosteric Modulators of AMPA Receptors: Synthesis and Study of Their Functional Activity by Radioligand-Receptor Binding Analysis
Golubeva E, Lavrov M, Veremeeva P, Vyunova T, Shevchenko K, Topchiy M, et al.
Int J Mol Sci . 2023 Jun; 24(12). PMID: 37373440
The synthetic approaches to three new AMPA receptor modulators-derivatives of 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.1]tetradecane-4,8,12-trione-had been developed and all steps of synthesis were optimized. The structures of the compounds contain tricyclic cage and indane...
2.
Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects
Golubeva E, Lavrov M, Radchenko E, Palyulin V
Biomolecules . 2023 Jan; 13(1). PMID: 36671441
L-Glutamic acid is the main excitatory neurotransmitter in the central nervous system (CNS). Its associated receptors localized on neuronal and non-neuronal cells mediate rapid excitatory synaptic transmission in the CNS...
3.
Novel Nanomolar Allosteric Modulators of AMPA Receptor of Bis(pyrimidine) Series: Synthesis, Biotesting and SAR Analysis
Sedenkova K, Zverev D, Nazarova A, Lavrov M, Radchenko E, Grishin Y, et al.
Molecules . 2022 Dec; 27(23). PMID: 36500341
Positive allosteric modulators (PAMs) of AMPA receptors represent attractive candidates for the development of drugs for the treatment of cognitive and neurodegenerative disorders. Dimeric molecules have been reported to have...
4.
Characterization of a New Positive Allosteric Modulator of AMPA Receptors - PAM-43: Specific Binding of the Ligand and its Ability to Potentiate AMPAR Currents
Vyunova T, Andreeva L, Shevchenko K, Grigoriev V, Palyulin V, Lavrov M, et al.
Curr Mol Pharmacol . 2020 Mar; 13(3):216-223. PMID: 32124706
Background: Currently, the most dynamic areas in the glutamate receptor system neurobiology are the identification and development of positive allosteric modulators (PAMs) of glutamate ionotropic receptors. PAM-based drugs are of...
5.
Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series
Nazarova A, Sedenkova K, Karlov D, Lavrov M, Grishin Y, Kuznetsova T, et al.
Medchemcomm . 2019 Dec; 10(9):1615-1619. PMID: 31803402
The first example of a novel class of AMPA receptor positive allosteric modulators of the bis(pyrimidine) series having a hydroquinone linker has been obtained and showed a potency to increase...
6.
Novel Positive Allosteric Modulators of AMPA Receptors Based on 3,7-Diazabicyclo[3.3.1]nonane Scaffold
Lavrov M, Karlov D, Voronina T, Grigoriev V, Ustyugov A, Bachurin S, et al.
Mol Neurobiol . 2019 Sep; 57(1):191-199. PMID: 31515692
A series of new positive allosteric modulators (PAMs) of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors based on 3,7-diazabicyclo[3.3.1]nonane scaffold have been designed, synthesized, and analyzed. In electrophysiological patch clamp studies, several compounds...
7.
MM-GBSA and MM-PBSA performance in activity evaluation of AMPA receptor positive allosteric modulators
Karlov D, Lavrov M, Palyulin V, Zefirov N
J Biomol Struct Dyn . 2017 Jul; 36(10):2508-2516. PMID: 28749200
No abstract available.