Motoyuki Hattori
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Explore the profile of Motoyuki Hattori including associated specialties, affiliations and a list of published articles.
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58
Citations
1401
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Recent Articles
1.
Ma J, Song X, Funato Y, Teng X, Huang Y, Miki H, et al.
Structure
. 2024 Nov;
33(1):104-114.e3.
PMID: 39510076
The CNNM/CorC Mg transporters are widely conserved in eukaryotes (cyclin M [CNNM]) and prokaryotes (CorC) and participate in various biological processes. Previous structural analyses of the CorC transmembrane domain in...
2.
Frank C, Khoshouei A, FuB L, Schiwietz D, Putz D, Weber L, et al.
Science
. 2024 Oct;
386(6720):439-445.
PMID: 39446959
Machine learning (ML)-based design approaches have advanced the field of de novo protein design, with diffusion-based generative methods increasingly dominating protein design pipelines. Here, we report a "hallucination"-based protein design...
3.
Jin F, Lin Y, Wang R, Xie T, Zhao Y, Shen C, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(44):e2405659121.
PMID: 39441630
Cys-loop receptors are a large superfamily of pentameric ligand-gated ion channels with various physiological roles, especially in neurotransmission in the central nervous system. Among them, zinc-activated channel (ZAC) is a...
4.
Huang Y, Zhang Z, Hattori M
J Mol Biol
. 2024 Oct;
436(22):168809.
PMID: 39362625
Membrane proteins are involved in numerous biological processes and represent more than half of all drug targets; thus, structural information on these proteins is invaluable. However, the low expression level...
5.
Sumino A, Sumikama T, Zhao Y, Flechsig H, Umeda K, Kodera N, et al.
ACS Nano
. 2024 Aug;
18(36):25018-25035.
PMID: 39180186
α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid glutamate receptors (AMPARs) enable rapid excitatory synaptic transmission by localizing to the postsynaptic density of glutamatergic spines. AMPARs possess large extracellular N-terminal domains (NTDs), which are crucial...
6.
Sheng D, Yue C, Jin F, Wang Y, Ichikawa M, Yu Y, et al.
Elife
. 2024 Apr;
12.
PMID: 38578670
P2X receptors are extracellular ATP-gated ion channels that form homo- or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play...
7.
Ma X, Yue C, Liu Y, Yang Y, Wang J, Yang X, et al.
Comput Struct Biotechnol J
. 2024 Jan;
23:295-308.
PMID: 38173879
P2X receptors (P2X1-7) are non-selective cation channels involved in many physiological activities such as synaptic transmission, immunological modulation, and cardiovascular function. These receptors share a conserved mechanism to sense extracellular...
8.
Shen C, Zhang Y, Cui W, Zhao Y, Sheng D, Teng X, et al.
Nat Commun
. 2023 Oct;
14(1):6437.
PMID: 37833294
P2X receptors are ATP-activated cation channels, and the P2X4 subtype plays important roles in the immune system and the central nervous system, particularly in neuropathic pain. Therefore, P2X4 receptors are...
9.
Sumino A, Zhao Y, Mukai D, Sumikama T, Puppulin L, Hattori M, et al.
Proc Natl Acad Sci U S A
. 2023 May;
120(20):e2301013120.
PMID: 37155841
Transient receptor potential vanilloid member 1 (TRPV1) is a heat and capsaicin receptor that allows cations to permeate and cause pain. As the molecular basis for temperature sensing, the heat...
10.
Wang M, Zhao Y, Hayashi Y, Ito K, Hattori M
Acta Biochim Biophys Sin (Shanghai)
. 2023 Apr;
55(4):683-690.
PMID: 37097058
MgtE is a Mg -selective channel regulated by the intracellular Mg concentration. MgtE family proteins are highly conserved in all domains of life and contribute to cellular Mg homeostasis. In...