Moritz Middelhoff
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Explore the profile of Moritz Middelhoff including associated specialties, affiliations and a list of published articles.
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24
Citations
995
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Recent Articles
1.
Ragab M, Wieland J, Avila de Melo C, Agibalova T, Ermolova A, Durner N, et al.
J Crohns Colitis
. 2025 Mar;
PMID: 40052554
Background & Aims: Epithelial muscarinic acetylcholine receptor subtype 3 (M3R) signaling modulates intestinal stem and progenitor cell function, yet its impact on colonic homeostasis remains unclear. Hence, this study explores...
2.
Agibalova T, Hempel A, Maurer H, Ragab M, Ermolova A, Wieland J, et al.
Stem Cell Res Ther
. 2024 Oct;
15(1):348.
PMID: 39380035
Background: Vasoactive intestinal peptide (VIP) is a neuronal peptide with prominent distribution along the enteric nervous system. While effects of VIP on intestinal motility, mucosal vasodilation, secretion, and mucosal immune...
3.
Valenti G, Laise P, Takahashi R, Wu F, Ruan T, Vasciaveo A, et al.
bioRxiv
. 2024 Sep;
PMID: 39257805
expression defines a rare population of cells in the normal pancreas whose frequency is increased at early stages of pancreatic tumorigenesis. The identity and the precise roles of expressing cells...
4.
Malagola E, Vasciaveo A, Ochiai Y, Kim W, Zheng B, Zanella L, et al.
Cell
. 2024 Jun;
187(12):3056-3071.e17.
PMID: 38848678
The currently accepted intestinal epithelial cell organization model proposes that Lgr5 crypt-base columnar (CBC) cells represent the sole intestinal stem cell (ISC) compartment. However, previous studies have indicated that Lgr5...
5.
Schult D, Maurer H, Frolova M, Ringelhan M, Mayr U, Ulrich J, et al.
Clin Transl Gastroenterol
. 2023 Dec;
15(2):e00660.
PMID: 38088370
Introduction: The identification of risk factors for precursor lesions of colorectal cancer (CRC) holds great promise in the context of prevention. With this study, we aimed to identify patient characteristics...
6.
Jiang Z, Wu F, Laise P, Takayuki T, Na F, Kim W, et al.
Cell Stem Cell
. 2023 Aug;
30(8):1091-1109.e7.
PMID: 37541213
While adult pancreatic stem cells are thought not to exist, it is now appreciated that the acinar compartment harbors progenitors, including tissue-repairing facultative progenitors (FPs). Here, we study a pancreatic...
7.
Ralser A, Dietl A, Jarosch S, Engelsberger V, Wanisch A, Janssen K, et al.
Gut
. 2023 Apr;
72(7):1258-1270.
PMID: 37015754
Objective: infection is the most prevalent bacterial infection worldwide. Besides being the most important risk factor for gastric cancer development, epidemiological data show that infected individuals harbour a nearly twofold...
8.
Gut Microbial Disruption in Critically Ill Patients with COVID-19-Associated Pulmonary Aspergillosis
Maurer H, Schult D, Koyumdzhieva P, Reitmeier S, Middelhoff M, Rasch S, et al.
J Fungi (Basel)
. 2022 Dec;
8(12).
PMID: 36547598
Objectives: COVID-19 disease can be exacerbated by superinfection (CAPA). However, the causes of CAPA are not yet fully understood. Recently, alterations in the gut microbiome have been associated with a...
9.
Middelhoff M, Valenti G, Tomassoni L, Ochiai Y, Belin B, Takahashi R, et al.
Am J Physiol Gastrointest Liver Physiol
. 2022 Mar;
322(6):G583-G597.
PMID: 35319286
Intestinal ganglionic cells in the adult enteric nervous system (ENS) are continually exposed to stimuli from the surrounding microenvironment and need at times to respond to disturbed homeostasis following acute...
10.
Schult D, Reitmeier S, Koyumdzhieva P, Lahmer T, Middelhoff M, Erber J, et al.
Gut Microbes
. 2022 Feb;
14(1):2031840.
PMID: 35174781
There is a growing debate about the involvement of the gut microbiome in COVID-19, although it is not conclusively understood whether the microbiome has an impact on COVID-19, or vice...