Moran Frenkel-Pinter
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Explore the profile of Moran Frenkel-Pinter including associated specialties, affiliations and a list of published articles.
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31
Citations
615
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Recent Articles
1.
Matange K, Rajaei V, Capera-Aragones P, Costner J, Robertson A, Kim J, et al.
Nat Chem
. 2025 Feb;
PMID: 39939341
Many open questions about the origins of life are centred on the generation of complex chemical species. Past work has characterized specific chemical reactions that might lead to biological molecules....
2.
Ezerzer Y, Frenkel-Pinter M, Kolodny R, Ben-Tal N
Curr Opin Struct Biol
. 2025 Feb;
91:102996.
PMID: 39919321
Recent findings increasingly suggest the emergence of proteins by mix and match of short peptides, or 'building blocks'. What are these building blocks, and how did they evolve into contemporary...
3.
Matange K, Marland E, Frenkel-Pinter M, Williams L
Acc Chem Res
. 2025 Feb;
58(5):659-672.
PMID: 39905926
ConspectusA holistic description of biopolymers and their evolutionary origins will contribute to our understanding of biochemistry, biology, the origins of life, and signatures of life outside our planet. While biopolymer...
4.
Edri R, Williams L, Frenkel-Pinter M
Acc Chem Res
. 2024 Oct;
57(21):3081-3092.
PMID: 39373892
ConspectusThe mystery of the origins of life is one of the most difficult yet intriguing challenges to which humanity has grappled. How did biopolymers emerge in the absence of enzymes...
5.
Edri R, Fisher S, Menor-Salvan C, Williams L, Frenkel-Pinter M
FEBS Lett
. 2023 Oct;
597(23):2879-2896.
PMID: 37884438
The origins of biopolymers pose fascinating questions in prebiotic chemistry. The marvelous assembly proficiencies of biopolymers suggest they are winners of a competitive evolutionary process. Sophisticated molecular assembly is ubiquitous...
6.
Guth-Metzler R, Mohamed A, Cowan E, Henning A, Ito C, Frenkel-Pinter M, et al.
Nucleic Acids Res
. 2023 Mar;
51(8):3529-3539.
PMID: 36987860
Magnesium, the most abundant divalent cation in cells, catalyzes RNA cleavage but also promotes RNA folding. Because folding can protect RNA from cleavage, we predicted a 'Goldilocks landscape', with local...
7.
Llop E, Arda A, Zacco E, OFlaherty R, Garcia-Ayllon M, Aureli M, et al.
Glycoconj J
. 2022 Aug;
39(5):579-586.
PMID: 36001187
The Cost Action "Innovation with glycans: new frontiers from synthesis to new biological targets" (INNOGLY) hosted the Workshop "Neuroglycoproteins in health and disease", in Alicante, Spain, on March 2022. This...
8.
C M, Frenkel-Pinter M, Smith K, Rivera-Santana V, Sargon A, Jacobson K, et al.
JACS Au
. 2022 Jul;
2(6):1395-1404.
PMID: 35783166
The high kinetic barrier to amide bond formation has historically placed narrow constraints on its utility in reversible chemistry applications. Slow kinetics has limited the use of amides for the...
9.
Frenkel-Pinter M, Bouza M, Fernandez F, Leman L, Williams L, Hud N, et al.
Nat Commun
. 2022 May;
13(1):2569.
PMID: 35562173
It is widely assumed that the condensation of building blocks into oligomers and polymers was important in the origins of life. High activation energies, unfavorable thermodynamics and side reactions are...
10.
Frenkel-Pinter M, Sargon A, Glass J, Hud N, Williams L
RSC Adv
. 2022 Apr;
11(6):3534-3538.
PMID: 35424306
Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain...