Monique A J van der Vleuten
Overview
Explore the profile of Monique A J van der Vleuten including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
5
Citations
114
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Groothuis P, Jacobs D, Hermens I, Damming D, Berentsen K, Mattaar-Hepp E, et al.
Mol Cancer Ther
. 2023 Apr;
22(6):765-777.
PMID: 37042205
MET, the cell-surface receptor for the hepatocyte growth factor/scatter factor, which is widely overexpressed in various solid cancer types, is an attractive target for the development of antibody-based therapeutics. BYON3521...
2.
Ubink R, Dirksen E, Rouwette M, Bos E, Janssen I, Egging D, et al.
Mol Cancer Ther
. 2018 Aug;
17(11):2389-2398.
PMID: 30093567
Carboxylesterase 1c (CES1c) is responsible for linker-drug instability and poor pharmacokinetics (PK) of several antibody-drug conjugates (ADC) in mice, but not in monkeys or humans. Preclinical development of these ADCs...
3.
van der Lee M, Groothuis P, Ubink R, van der Vleuten M, van Achterberg T, Loosveld E, et al.
Mol Cancer Ther
. 2015 Jan;
14(3):692-703.
PMID: 25589493
SYD985 is a HER2-targeting antibody-drug conjugate (ADC) based on trastuzumab and vc-seco-DUBA, a cleavable linker-duocarmycin payload. To evaluate the therapeutic potential of this new ADC, mechanistic in vitro studies and...
4.
Toonen E, Laskewitz A, van Dijk T, Bleeker A, Grefhorst A, Schouten A, et al.
PLoS One
. 2014 Sep;
9(9):e98684.
PMID: 25181348
Prednisolone and other glucocorticoids (GCs) are potent anti-inflammatory drugs, but chronic use is hampered by metabolic side effects. Therefore, there is an urgent medical need for improved GCs that are...
5.
Dulos J, van der Vleuten M, Kavelaars A, Heijnen C, Boots A
Arthritis Rheum
. 2005 Mar;
52(3):770-8.
PMID: 15751070
Objective: The cytochrome P450 enzyme CYP7B catalyzes the conversion of dehydroepiandrosterone (DHEA) into 7alpha-hydroxy-DHEA (7alpha-OH-DHEA). This metabolite can stimulate the immune response. We previously reported that the severity of murine...