Mona Seifert
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Explore the profile of Mona Seifert including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
84
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Recent Articles
1.
Dohnalova H, Seifert M, Matouskova E, Klein M, Papini F, Lipfert J, et al.
J Phys Chem B
. 2024 Jan;
128(3):664-675.
PMID: 38197365
RNA plays critical roles in the transmission and regulation of genetic information and is increasingly used in biomedical and biotechnological applications. Functional RNAs contain extended double-stranded regions, and the structure...
2.
Bera S, America P, Maatsola S, Seifert M, Ostrofet E, Cnossen J, et al.
Nucleic Acids Res
. 2022 Jul;
50(13):7511-7528.
PMID: 35819191
Transcription initiation is the first step in gene expression, and is therefore strongly regulated in all domains of life. The RNA polymerase (RNAP) first associates with the initiation factor $\sigma$...
3.
Seifert M, Bera S, van Nies P, Kirchdoerfer R, Shannon A, Le T, et al.
Elife
. 2021 Oct;
10.
PMID: 34617885
The absence of 'shovel-ready' anti-coronavirus drugs during vaccine development has exceedingly worsened the SARS-CoV-2 pandemic. Furthermore, new vaccine-resistant variants and coronavirus outbreaks may occur in the near future, and we...
4.
Bera S, Seifert M, Kirchdoerfer R, van Nies P, Wubulikasimu Y, Quack S, et al.
Cell Rep
. 2021 Aug;
36(9):109650.
PMID: 34433083
Coronaviruses have evolved elaborate multisubunit machines to replicate and transcribe their genomes. Central to these machines are the RNA-dependent RNA polymerase subunit (nsp12) and its intimately associated cofactors (nsp7 and...
5.
Seifert M, Bera S, van Nies P, Kirchdoerfer R, Shannon A, Le T, et al.
bioRxiv
. 2021 Apr;
PMID: 33851161
Teaser: We revise Remdesivir's mechanism of action and reveal SARS-CoV-2 ability to evade interferon-induced antiviral ddhCTP.
6.
Bera S, Seifert M, Kirchdoerfer R, van Nies P, Wubulikasimu Y, Quack S, et al.
bioRxiv
. 2021 Apr;
PMID: 33791706
Coronaviruses have evolved elaborate multisubunit machines to replicate and transcribe their genomes. Central to these machines are the RNA-dependent RNA polymerase subunit (nsp12) and its intimately associated cofactors (nsp7 and...
7.
Seifert M, van Nies P, Papini F, Arnold J, Poranen M, Cameron C, et al.
Nucleic Acids Res
. 2020 Apr;
48(10):5591-5602.
PMID: 32286652
RNA virus survival depends on efficient viral genome replication, which is performed by the viral RNA dependent RNA polymerase (RdRp). The recent development of high throughput magnetic tweezers has enabled...
8.
Papini F, Seifert M, Dulin D
Nucleic Acids Res
. 2019 Oct;
47(22):e144.
PMID: 31584079
Single molecule biophysics experiments have enabled the observation of biomolecules with a great deal of precision in space and time, e.g. nucleic acids mechanical properties and protein-nucleic acids interactions using...