Momoko Higuchi
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Explore the profile of Momoko Higuchi including associated specialties, affiliations and a list of published articles.
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7
Citations
85
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Recent Articles
1.
Ohnami S, Naito M, Kawase H, Higuchi M, Hasebe S, Takasu K, et al.
JCI Insight
. 2024 Dec;
9(23).
PMID: 39641273
The opioid system plays crucial roles in modulating social behaviors in both humans and animals. However, the pharmacological profiles of opioids regarding social behavior and their therapeutic potential remain unclear....
2.
Yokoyama R, Ago Y, Igarashi H, Higuchi M, Tanuma M, Shimazaki Y, et al.
Mol Psychiatry
. 2024 Feb;
29(5):1406-1416.
PMID: 38388704
Chronic social isolation increases the risk of mental health problems, including cognitive impairments and depression. While subanesthetic ketamine is considered effective for cognitive impairments in patients with depression, the neural...
3.
Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Igarashi H, Seiriki K, et al.
J Pharmacol Sci
. 2024 Jan;
154(2):72-76.
PMID: 38246730
Alternatives to ketamine without psychotomimetic properties for the treatment of depression have attracted much attention. Here, we examined the anti-despair and anti-anhedonia effects of the ketamine metabolites (S)-norketamine ((S)-NK), (R)-NK,...
4.
Yokoyama R, Higuchi M, Tanabe W, Tsukada S, Naito M, Yamaguchi T, et al.
Pharmacol Biochem Behav
. 2020 Feb;
191:172876.
PMID: 32088360
Clinical and preclinical studies have shown that the N-methyl-d-aspartate receptor antagonist ketamine exerts rapid and long-lasting antidepressant effects. Although ketamine metabolites might also have potential antidepressant properties, controversial results have...
5.
Ago Y, Tanabe W, Higuchi M, Tsukada S, Tanaka T, Yamaguchi T, et al.
Int J Neuropsychopharmacol
. 2019 Jul;
22(10):665-674.
PMID: 31325908
Background: Although recent studies provide insight into the molecular mechanisms of the effects of ketamine, the antidepressant mechanism of ketamine enantiomers and their metabolites is not fully understood. In view...
6.
Kawase H, Ago Y, Naito M, Higuchi M, Hara Y, Hasebe S, et al.
Pharmacol Biochem Behav
. 2018 Nov;
176:1-5.
PMID: 30419271
Growing evidence suggests pivotal roles for epigenetic mechanisms in both animal models of and individuals with autism spectrum disorders (ASD). Neuron-restrictive silencer factor (NRSF) binds to neuron-restrictive silencing elements in...
7.
Hara Y, Ago Y, Higuchi M, Hasebe S, Nakazawa T, Hashimoto H, et al.
Horm Behav
. 2017 Sep;
96:130-136.
PMID: 28942000
Recent studies have reported that oxytocin ameliorates behavioral abnormalities in both animal models and individuals with autism spectrum disorders (ASD). However, the mechanisms underlying the ameliorating effects of oxytocin remain...