Molly E McFadden
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Explore the profile of Molly E McFadden including associated specialties, affiliations and a list of published articles.
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11
Citations
284
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Recent Articles
1.
Sun Y, McFadden M, Osler S, Barber R, Robb M
Chem Sci
. 2023 Oct;
14(38):10494-10499.
PMID: 37800007
In contrast to common angular naphthopyrans that exhibit strong photochromic and mechanochromic behavior, constitutionally isomeric linear naphthopyrans are typically not photochromic, due to the putative instability of the completely dearomatized...
2.
McFadden M, Barber R, Overholts A, Robb M
Chem Sci
. 2023 Sep;
14(37):10041-10067.
PMID: 37772118
Naphthopyran molecular switches undergo a ring-opening reaction upon external stimulation to generate intensely colored merocyanine dyes. Their unique modularity and synthetic accessibility afford exceptional control over their properties and stimuli-responsive...
3.
Yao Y, McFadden M, Luo S, Barber R, Kang E, Bar-Zion A, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(39):e2309822120.
PMID: 37725651
External control of chemical reactions in biological settings with spatial and temporal precision is a grand challenge for noninvasive diagnostic and therapeutic applications. While light is a conventional stimulus for...
4.
McFadden M, Overholts A, Osler S, Robb M
ACS Macro Lett
. 2023 Mar;
12(4):440-445.
PMID: 36944217
Understanding structure-mechanochemical reactivity relationships is important for informing the rational design of new stimuli-responsive polymers. To this end, establishing accurate reaction kinetics for mechanophore activation is a key objective. Here,...
5.
McFadden M, Osler S, Sun Y, Robb M
J Am Chem Soc
. 2022 Dec;
144(49):22391-22396.
PMID: 36459076
Multimodal mechanophores that exhibit complex mechanochromic behavior beyond the typical binary response are capable of distinguishing between multiple stress states through discrete changes in color. Naphthodipyran photoswitches contain two pyran...
6.
Newman J, Chopra J, Shah P, Shi E, McFadden M, Horness R, et al.
Mol Microbiol
. 2021 Sep;
116(4):1173-1188.
PMID: 34468051
The quorum-sensing signaling systems in Vibrio bacteria converge to control levels of the master transcription factors LuxR/HapR, a family of highly conserved proteins that regulate gene expression for bacterial behaviors....
7.
Versaw B, McFadden M, Husic C, Robb M
Chem Sci
. 2021 Jun;
11(17):4525-4530.
PMID: 34122911
Mechanochromic molecular force probes conveniently report on stress and strain in polymeric materials through straightforward visual cues. We capitalize on the versatility of the naphthopyran framework to design a series...
8.
McFadden M, Robb M
J Am Chem Soc
. 2021 May;
143(21):7925-7929.
PMID: 34009958
We report the discovery of a 2-naphtho[1,2-]pyran mechanophore that produces a permanent merocyanine dye upon mechanochemical activation, in contrast to the reversible product generated photochemically. Experiments suggest that the irreversibility...
9.
Funabashi M, Grove T, Wang M, Varma Y, McFadden M, Brown L, et al.
Nature
. 2020 Jun;
582(7813):566-570.
PMID: 32555455
The gut microbiota synthesize hundreds of molecules, many of which influence host physiology. Among the most abundant metabolites are the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA),...
10.
McFadden M, Robb M
J Am Chem Soc
. 2019 Jul;
141(29):11388-11392.
PMID: 31282668
We report a bis-naphthopyran mechanophore that exhibits force-dependent changes in visible absorption. A series of polymers incorporating a chain-centered bis-naphthopyran mechanophore was synthesized and mechanically activated using ultrasonication. By varying...