Mohammed Dehbi
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Explore the profile of Mohammed Dehbi including associated specialties, affiliations and a list of published articles.
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Articles
32
Citations
806
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Recent Articles
1.
Nejat S, Menikdiwela K, Efotte A, Scoggin S, Vandanmagsar B, Thornalley P, et al.
Genes (Basel)
. 2023 Oct;
14(10).
PMID: 37895206
Several pathways and/or genes have been shown to be dysregulated in obesity-induced insulin resistance (IR) and type 2 diabetes (T2D). We previously showed, for the first time, impaired expression of...
2.
Islam Z, Diane A, Khattab N, Dehbi M, Thornalley P, Kolatkar P
PLoS One
. 2023 Aug;
18(8):e0290340.
PMID: 37594932
Metabolic stress involved in several dysregulation disorders such as type 2 diabetes mellitus (T2DM) results in down regulation of several heat shock proteins (HSPs) including DNAJB3. This down regulation of...
3.
Diane A, Abunada H, Khattab N, Moin A, Butler A, Dehbi M
Ageing Res Rev
. 2021 Mar;
67:101313.
PMID: 33676026
Insulin resistance (IR) underpins a wide range of metabolic disorders including type 2 diabetes (T2D), metabolic syndrome and cardiovascular diseases. IR is characterized by a marked reduction in the magnitude...
4.
Moin A, Nandakumar M, Diane A, Dehbi M, Butler A
Front Immunol
. 2021 Feb;
11:612584.
PMID: 33584694
Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease characterized by recognition of pancreatic β-cell proteins as self-antigens, called autoantigens (AAgs), followed by loss of pancreatic β-cells. (Pre-)proinsulin ([P]PI),...
5.
Diane A, Mahmoud N, Bensmail I, Khattab N, Abunada H, Dehbi M
Sci Rep
. 2020 Nov;
10(1):20482.
PMID: 33235302
Persistent ER stress, mitochondrial dysfunction and failure of the heat shock response (HSR) are fundamental hallmarks of insulin resistance (IR); one of the early core metabolic aberrations that leads to...
6.
Madhu D, Khadir A, Hammad M, Kavalakatt S, Dehbi M, Al-Mulla F, et al.
Biochim Biophys Acta Proteins Proteom
. 2020 Apr;
1868(7):140426.
PMID: 32272193
Lipotoxicity, an important factor in the pathogenesis of diabetes, leads to defective β-cell proliferation and increased apoptosis. Glucagon-like peptide-1 (GLP-1) analogs, which are used to treat type 2 diabetes, reduce...
7.
Arredouani A, Diane A, Khattab N, Bensmail I, Aoude I, Chikri M, et al.
Sci Rep
. 2019 Mar;
9(1):4772.
PMID: 30886231
Failure of the heat shock response is a key event that leads to insulin resistance and type 2 diabetes. We recently showed that DNAJB3 co-chaperone is downregulated in obese and...
8.
Khadir A, Kavalakatt S, Dehbi M, Alarouj M, Bennakhi A, Tiss A, et al.
Dis Markers
. 2019 Jan;
2018:9529621.
PMID: 30647800
Background: Cardiovascular disease (CVD) risks persist in patients despite the use of conventional treatments. This might be due to chronic inflammation as reflected in epidemiological studies associating circulating low-grade inflammatory...
9.
Khadir A, Kavalakatt S, Cherian P, Warsame S, Abubaker J, Dehbi M, et al.
Front Endocrinol (Lausanne)
. 2018 Feb;
9:16.
PMID: 29467719
Heat shock protein 60 (HSP60) is a key protein in the crosstalk between cellular stress and inflammation. However, the status of HSP60 in diabetes and obesity is unclear. In the...
10.
Khadir A, Kavalakatt S, Abubaker J, Cherian P, Madhu D, Al-Khairi I, et al.
Metabolism
. 2016 Aug;
65(9):1409-20.
PMID: 27506747
Background And Objectives: Perturbation of the endoplasmic reticulum (ER) homeostasis has emerged as one of the prominent features of obesity and diabetes. This occurs when the adaptive unfolded protein response...