Mohammed Alrouji
Overview
Explore the profile of Mohammed Alrouji including associated specialties, affiliations and a list of published articles.
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Articles
53
Citations
211
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Recent Articles
1.
Alsaleem M, Al-Kuraishy H, Al-Gareeb A, Abdel-Fattah M, Alrouji M, Al-Harchan N, et al.
J Cell Mol Med
. 2025 Mar;
29(5):e70378.
PMID: 40040308
Alzheimer's disease (AD) is a neurodegenerative disease caused by the progressive deposition of extracellular amyloid beta (Aβ) and intracellular neurofibrillary tangles (NFTs). Of note, metabolic disorders such as insulin resistance...
2.
Aljarba N, Al-Kuraishy H, Al-Gareeb A, Shokr M, Papadakis M, Alexiou A, et al.
Brain Res Bull
. 2025 Feb;
222:111236.
PMID: 39892578
The advanced glycation end-products (AGEs) are toxic molecules result from non-enzymatic interactions of sugar with lipids or proteins. AGEs promote the generation of reactive oxygen species that induce the release...
3.
Alrouji M, Yasmin S, Alshammari M, Alhumaydhi F, Sharaf S, Shahwan M, et al.
PLoS One
. 2025 Jan;
20(1):e0316343.
PMID: 39752394
Epigenetic processes are the critical events in carcinogenesis. Histone modification plays a crucial role in gene expression regulation, where histone deacetylases (HDACs) are key players in epigenetic processes. Inhibiting HDACs...
4.
Alsaleem M, Al-Kuraishy H, Al-Gareeb A, Albuhadily A, Alrouji M, Yassen A, et al.
Cell Mol Neurobiol
. 2024 Dec;
45(1):8.
PMID: 39719518
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment and memory deficit. Even with extensive research and studies, presently, there is no effective treatment for the management of...
5.
Alrouji M, Yasmin S, Alshammari M, Alhumaydhi F, Sharaf S, Shahwan M, et al.
PLoS One
. 2024 Dec;
19(12):e0316010.
PMID: 39700174
Alzheimer's disease (AD) is characterized by the aggregation of amyloid β (Aβ) peptides and the formation of plaques in the brain, primarily derived from the proteolytic degradation of amyloid precursor...
6.
Alrouji M, Furkan M, Alnuaimi G, Yasmin S, Alhumaydhi F, Khan R, et al.
Int J Biol Macromol
. 2024 Dec;
289:138829.
PMID: 39694350
In recent times, neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease (PD) and others, represent a major global health challenge with increasing prevalence and significant socio-economic impact. These...
7.
Zaidalkilani A, Al-Kuraishy H, Al-Gareeb A, Alexiou A, Papadakis M, Al-Farga A, et al.
J Cell Mol Med
. 2024 Dec;
28(23):e70067.
PMID: 39663784
The metabolic syndrome (MetS) is a clustering of abdominal obesity, hypertension, hyperglycaemia, hypertriglyceridemia and low high-density lipoprotein (HDL) level. MetS development is affected by endocrine hormones such as prolactin (PRL)...
8.
Alanazi Y, Al-Kuraishy H, Al-Gareeb A, Alexiou A, Papadakis M, Bahaa M, et al.
J Cell Mol Med
. 2024 Dec;
28(23):e70240.
PMID: 39656379
Type 2 diabetes mellitus (T2DM) is developed due to the development of insulin resistance (IR) and pancreatic β cell dysfunction with subsequent hyperglycaemia. Hyperglycaemia-induced oxidative stress and endoplasmic reticulum (ER)...
9.
Alrouji M, Venkatesan K, Alshammari M, Alhumaydhi F, Shafi S, Sharaf S, et al.
Front Pharmacol
. 2024 Nov;
15:1488585.
PMID: 39611171
Histone deacetylase 8 (HDAC8) is a member of class I histone deacetylases (HDACs) that catalyzes the deacetylation of both histone and non-histone proteins. Dysregulation and overexpression of HDAC8 are implicated...
10.
Alrouji M, Anwar S, Venkatesan K, Shahwan M, Hassan M, Islam A, et al.
Ageing Res Rev
. 2024 Nov;
102:102575.
PMID: 39515619
Ageing is a major risk factor for various chronic diseases and offers a potential target for developing novel and broadly effective preventatives or therapeutics for age-related conditions, including those affecting...