Mohammed Abdelsaid
Overview
Explore the profile of Mohammed Abdelsaid including associated specialties, affiliations and a list of published articles.
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27
Citations
536
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Recent Articles
1.
Heath S, Hermanns V, Coucha M, Abdelsaid M
Transl Stroke Res
. 2024 Oct;
PMID: 39354270
COVID-19 increases the risk for acute ischemic stroke, yet the molecular mechanisms are unclear and remain unresolved medical challenges. We hypothesize that the SARS-CoV-2 spike protein exacerbates stroke and cerebrovascular...
2.
Meier M, Becker S, Levine E, DuFresne O, Foster K, Moore J, et al.
PLoS One
. 2024 Jul;
19(7):e0304135.
PMID: 39074114
Purpose: This study addressed the following questions: 1) Does prior treatment with RAS modulator worsen COVID-19-induced cerebrovascular and cognitive dysfunction? 2) Can post-treatment with RAS modulator improve cognitive performance and...
3.
Burnett F, Coucha M, Bolduc D, Hermanns V, Heath S, Abdelghani M, et al.
Int J Mol Sci
. 2023 Nov;
24(22).
PMID: 38003584
Diabetics are more vulnerable to SARS-CoV-2 neurological manifestations. The molecular mechanisms of SARS-CoV-2-induced cerebrovascular dysfunction in diabetes are unclear. We hypothesize that SARS-CoV-2 exacerbates diabetes-induced cerebrovascular oxidative stress and inflammation...
4.
Li W, Abdul Y, Chandran R, Jamil S, Ward R, Abdelsaid M, et al.
Am J Physiol Heart Circ Physiol
. 2022 Dec;
324(2):H212-H225.
PMID: 36563009
Diabetes increases the risk of poststroke cognitive impairment (PSCI). Greater hemorrhagic transformation (HT) after stroke is associated with vasoregression and cognitive decline in male diabetic rats. Iron chelator deferoxamine (DFX)...
5.
GLP-1 receptor nitration contributes to loss of brain pericyte function in a mouse model of diabetes
Bailey J, Coucha M, Bolduc D, Burnett F, Barrett A, Ghaly M, et al.
Diabetologia
. 2022 Jun;
65(9):1541-1554.
PMID: 35687178
Aims/hypothesis: We have previously shown that diabetes causes pericyte dysfunction, leading to loss of vascular integrity and vascular cognitive impairment and dementia (VCID). Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs),...
6.
Greenway F, Loveridge B, Grimes R, Tucker T, Alexander M, Hepford S, et al.
Int J Mol Sci
. 2022 Feb;
23(3).
PMID: 35163806
Prevalence of type 2 diabetes increased from 2.5% of the US population in 1990 to 10.5% in 2018. This creates a major public health problem, due to increases in long-term...
7.
Abdul Y, Li W, Ward R, Abdelsaid M, Hafez S, Dong G, et al.
Transl Stroke Res
. 2020 Sep;
12(4):615-630.
PMID: 32875455
It is a clinically well-established fact that patients with diabetes have very poor stroke outcomes. Yet, the underlying mechanisms remain largely unknown. Our previous studies showed that male diabetic animals...
8.
Coucha M, Barrett A, Bailey J, Abdelghani M, Abdelsaid M
Vascul Pharmacol
. 2020 Jun;
131:106761.
PMID: 32585189
Aims: Diabetes-induced retinal vascular cell death aggravates diabetic retinopathy (DR) to the proliferative stage and blindness. Pericytes play a crucial role in retinal capillaries survival, stability, and angiogenesis. Ephrin-B2 is...
9.
Coucha M, Barrett A, Elgebaly M, Ergul A, Abdelsaid M
PLoS One
. 2019 Jan;
14(1):e0210523.
PMID: 30620753
We have previously shown that diabetes causes dysfunctional cerebral neovascularization that increases the risk for cerebrovascular disorders such as stroke and cognitive impairment. Pericytes (PCs) play a pivotal role in...
10.
Abdul Y, Abdelsaid M, Li W, Webb R, Sullivan J, Dong G, et al.
Mol Neurobiol
. 2018 Jun;
56(3):1607-1617.
PMID: 29909454
Diabetes increases the risk of occurrence and poor functional recovery after ischemic stroke injury. Previously, we have demonstrated greater hemorrhagic transformation (HT), edema, and more severe functional deficits after stroke...