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Mohammad Jamaluddin

Explore the profile of Mohammad Jamaluddin including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 31
Citations 1293
Followers 0
Related Specialties
Biochemistry
Cell Biology
Molecular Biology
Top 10 Co-Authors
Allan R Brasier
Bing Tian
Roberto P Garofalo
Yingxin Zhao
Antonella Casola
Shaofei Wang
Yueqing Zhang
Ayman Al-Hendy
Istvan Boldogh
Chukwudi B Edeh
Published In
J Virol
J Biol Chem
Cell Signal
Mol Cell Proteomics
Front Immunol
Affiliations
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Recent Articles
1.
B cell-specific mAb-siRNA conjugates improve experimental myasthenia
Ibtehaj N, Bahauddin A, Ivannikov M, Rytting E, Jamaluddin M, Liang Y, et al.
J Autoimmun . 2023 Jan; 135:102983. PMID: 36640636
Myasthenia gravis (MG) is a debilitating autoimmune disease characterized by muscle fatigue and weakness caused by autoantibody- and complement-mediated damage to the neuromuscular junction. This study sought to compare the...
2.
NRF2 Regulates Cystathionine Gamma-Lyase Expression and Activity in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus
Jamaluddin M, de Mello A, Tapryal N, Hazra T, Garofalo R, Casola A
Antioxidants (Basel) . 2022 Aug; 11(8). PMID: 36009301
Cystathionine-y-lyase (CSE) is a critical enzyme for hydrogen sulfide (HS) biosynthesis and plays a key role in respiratory syncytial virus (RSV) pathogenesis. The transcription factor NRF2 is the master regulator...
3.
Histone Deacetylase Isoforms Differentially Modulate Inflammatory and Autoantibody Responses in a Mouse Model of Myasthenia Gravis
Bahauddin A, Ivannikov M, Wang Z, Jamaluddin M, Curtis K, Ibtehaj N, et al.
Front Neurol . 2022 Feb; 12:804113. PMID: 35222229
Myasthenia gravis (MG) is an autoimmune disease characterized by chronic muscle fatigue and weakness caused by autoantibodies and complement-mediated damage at neuromuscular junctions. Histone deacetylases (HDACs) are crucial epigenetic regulators...
4.
Type II Epithelial-Mesenchymal Transition Upregulates Protein N-Glycosylation To Maintain Proteostasis and Extracellular Matrix Production
Zhang J, Jamaluddin M, Zhang Y, Widen S, Sun H, Brasier A, et al.
J Proteome Res . 2019 Aug; 18(9):3447-3460. PMID: 31424945
Type II epithelial-mesenchymal transition (EMT) plays a vital role in airway injury, repair, and remodeling. Triggered by growth factors, such as transforming growth factor beta (TGFβ), EMT induced a biological...
5.
PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome
McDonnell T, Willis R, Pericleous C, Ripoll V, Giles I, Isenberg D, et al.
Front Immunol . 2018 Nov; 9:2413. PMID: 30405613
APS is an autoimmune disease in which antiphospholipid antibodies (aPL) cause vascular thrombosis and pregnancy morbidity. In patients with APS, aPL exert pathogenic actions by binding serum beta-2-glycoprotein I (β2GPI)...
6.
Efficacy of Novel Highly Specific Bromodomain-Containing Protein 4 Inhibitors in Innate Inflammation-Driven Airway Remodeling
Tian B, Liu Z, Litvinov J, Maroto R, Jamaluddin M, Rytting E, et al.
Am J Respir Cell Mol Biol . 2018 Aug; 60(1):68-83. PMID: 30153047
NF-κB/RelA triggers innate inflammation by binding to bromodomain-containing protein 4 (BRD4), an atypical histone acetyltransferase (HAT). Although RelA·BRD4 HAT mediates acute neutrophilic inflammation, its role in chronic and functional airway...
7.
Effects of storage temperature on airway exosome integrity for diagnostic and functional analyses
Maroto R, Zhao Y, Jamaluddin M, Popov V, Wang H, Kalubowilage M, et al.
J Extracell Vesicles . 2017 Aug; 6(1):1359478. PMID: 28819550
: Extracellular vesicles contain biological molecules specified by cell-type of origin and modified by microenvironmental changes. To conduct reproducible studies on exosome content and function, storage conditions need to have...
8.
Systematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights into the Pathogenesis of Respiratory Syncytial Virus-Induced Lower Respiratory Tract Infections
Zhao Y, Jamaluddin M, Zhang Y, Sun H, Ivanciuc T, Garofalo R, et al.
J Immunol . 2017 Mar; 198(8):3345-3364. PMID: 28258195
Lower respiratory tract infections from respiratory syncytial virus (RSV) are due, in part, to secreted signals from lower airway cells that modify the immune response and trigger airway remodeling. To...
9.
Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation
Ijaz T, Jamaluddin M, Zhao Y, Zhang Y, Jay J, Finnerty C, et al.
Cell Death Dis . 2017 Feb; 8(2):e2606. PMID: 28182006
Transdifferentiation of quiescent dermal fibroblasts to secretory myofibroblasts has a central role in wound healing and pathological scar formation. This myofibroblast transdifferentiation process involves TGFβ-induced de novo synthesis of alpha...
10.
Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases
Yang J, Zhao Y, Kalita M, Li X, Jamaluddin M, Tian B, et al.
Mol Cell Proteomics . 2015 Jul; 14(10):2701-21. PMID: 26209609
Inducible transcriptional elongation is a rapid, stereotypic mechanism for activating immediate early immune defense genes by the epithelium in response to viral pathogens. Here, the recruitment of a multifunctional complex...