Mohammad B Uddin
Overview
Explore the profile of Mohammad B Uddin including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
153
Followers
0
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Recent Articles
1.
Roy T, Boateng S, Uddin M, Banang-Mbeumi S, Yadav R, Bock C, et al.
Cells
. 2023 Jun;
12(12).
PMID: 37371141
The dysregulated phosphatidylinositol-3-kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway has been implicated in various immune-mediated inflammatory and hyperproliferative dermatoses such as acne, atopic dermatitis, alopecia, psoriasis, wounds, and vitiligo,...
2.
W-M Fan T, Daneshmandi S, Cassel T, Uddin M, Sledziona J, Thompson P, et al.
J Immunol
. 2022 Sep;
209(9):1674-1690.
PMID: 36150727
Immunomodulatory (IM) metabolic reprogramming in macrophages (Mϕs) is fundamental to immune function. However, limited information is available for human Mϕs, particularly in response plasticity, which is critical to understanding the...
3.
Uddin M, Roy K, Hill R, Roy S, Gu X, Li L, et al.
Exp Cell Res
. 2022 May;
417(1):113210.
PMID: 35597298
Cancer cells acquire immunoediting ability to evade immune surveillance and thus escape eradication. It is widely known that mutant proteins encoded from tumor suppressor TP53 exhibit gain-of-function in cancer cells,...
4.
Roy K, Uddin M, Roy S, Hill R, Marshall J, Li Y, et al.
FASEB Bioadv
. 2020 Nov;
2(11):653-667.
PMID: 33205006
Glucosylceramide synthase (GCS) is a key enzyme catalyzing ceramide glycosylation to generate glucosylceramide (GlcCer), which in turn serves as the precursor for cells to produce glycosphingolipids (GSLs). In cell membranes,...
5.
Khiste S, Liu Z, Roy K, Uddin M, Hosain S, Gu X, et al.
Mol Cancer Ther
. 2019 Oct;
19(2):564-574.
PMID: 31645443
Ceramide (Cer) is an active cellular sphingolipid that can induce apoptosis or proliferation-arrest of cancer cells. Nanoparticle-based delivery offers an effective approach for overcoming bioavailability and biopharmaceutics issues attributable to...
6.
Uddin M, Roy K, Hosain S, Khiste S, Hill R, Jois S, et al.
Biochem Pharmacol
. 2018 Dec;
160:134-145.
PMID: 30578766
Mutant p53 proteins that promote cancer cell invasive growth, metastasis and drug resistance emerge as therapeutic targets. Previously, we reported that suppression of ceramide glycosylation restored wild-type p53 protein and...
7.
Chamcheu J, Rady I, Chamcheu R, Siddique A, Bloch M, Banang Mbeumi S, et al.
Int J Mol Sci
. 2018 Jun;
19(6).
PMID: 29914183
Non-melanoma skin cancers (NMSCs) are the leading cause of skin cancer-related morbidity and mortality. Effective strategies are needed to control NMSC occurrence and progression. Non-toxic, plant-derived extracts have been shown...
8.
Khiste S, Hosain S, Dong Y, Uddin M, Roy K, Hill R, et al.
Sci Rep
. 2017 Jun;
7(1):2976.
PMID: 28592871
Glucosylceramide synthase (GCS) is a rate-limiting enzyme catalyzing ceramide glycosylation, thereby regulating cellular ceramide levels and the synthesis of glycosphingolipids (GSLs) in cellular membranes. Alterations of GCS not only affect...
9.
Hosain S, Khiste S, Uddin M, Vorubindi V, Ingram C, Zhang S, et al.
Oncotarget
. 2016 Aug;
7(37):60575-60592.
PMID: 27517620
Missense mutation of tumor suppressor p53, which exhibits oncogenic gain-of-function (GOF), not only promotes tumor progression, but also diminishes therapeutic efficacies of cancer treatments. However, it remains unclear how a...