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Mohamad A Mikati

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Articles 193
Citations 2136
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Recent Articles
1.
Moya-Mendez M, Bidzimou M, Muralidharan P, Zhang Z, Ezekian J, Perelli R, et al.
JAMA Pediatr . 2025 Mar; PMID: 40029639
Importance: Alternating hemiplegia of childhood (AHC) is a disorder that can result from pathogenic variants in ATP1A3-encoded sodium-potassium adenosine triphosphatase alpha 3 (ATP1A3). While AHC is primarily a neurologic disease,...
2.
Funk E, Dear G, Moya-Mendez M, Landstrom A, Breglio A, Parker L, et al.
AANA J . 2025 Feb; 93(1):19-29. PMID: 39945148
People with alternating hemiplegia of childhood undergoing general anesthesia are at risk for severe complications including critical bradycardia and hemiplegic incidents. We performed a 10-year historical cohort study and completed...
3.
Hunanyan A, Verma A, Bidzimou M, Biswas D, Da Cruz E, Srour M, et al.
Epilepsia . 2025 Jan; 66(3):899-913. PMID: 39797721
Objective: This study was undertaken to test the following hypotheses in the Atp1a3 mouse (which carries the most common human ATP1A3 (the major subunit of the neuronal Na/K-adenosine triphosphatase [ATPase])...
4.
Kerr W, Acosta S, Kwan P, Worrell G, Mikati M
Epilepsy Curr . 2024 Nov; :15357597241238526. PMID: 39554271
Artificial intelligence, machine learning, and deep learning are increasingly being used in all medical fields including for epilepsy research and clinical care. Already there have been resultant cutting-edge applications in...
5.
Barcia Aguilar C, Amengual-Gual M, Brenton J, Chapman K, Clark J, Gaillard W, et al.
Seizure . 2024 Nov; 123:133-141. PMID: 39550933
Purpose: Evaluate the relationship between first and second-line medication dosing and progression to refractory status epilepticus (RSE) in children. Methods: This is a retrospective analysis of prospectively collected data from...
6.
Srour M, Bidzimou M, Muralidharan P, Mitchell S, Moya-Mendez M, Parker L, et al.
medRxiv . 2024 Sep; PMID: 39252916
Background: Alternating hemiplegia of childhood (AHC) is a rare disorder with both neurologic and cardiac manifestations. The ATP1A3-D801N variant is associated with a pathologically short QT interval and risk of...
7.
Dong P, Bakhurin K, Li Y, Mikati M, Cui J, Grill W, et al.
Proc Natl Acad Sci U S A . 2024 Jul; 121(28):e2403763121. PMID: 38968111
Advancing the mechanistic understanding of absence epilepsy is crucial for developing new therapeutics, especially for patients unresponsive to current treatments. Utilizing a recently developed mouse model of absence epilepsy carrying...
8.
Patel S, Maney K, Morris L, Papadopoulou M, Prange L, Boggs A, et al.
Eur J Paediatr Neurol . 2024 Feb; 49:55-59. PMID: 38367370
Background: Many alternating hemiplegia of childhood (AHC) patients have received Cannabidiol (CBD) but, to our knowledge, there are no published data available. Goals: Test the hypothesis that CBD has favorable...
9.
Panagiotakaki E, Tiziano F, Mikati M, Vijfhuizen L, Nicole S, Lesca G, et al.
Eur J Hum Genet . 2023 Dec; 32(2):224-231. PMID: 38097767
Alternating hemiplegia of childhood (AHC) is a rare neurodevelopment disorder that is typically characterized by debilitating episodic attacks of hemiplegia, seizures, and intellectual disability. Over 85% of individuals with AHC...
10.
Thamby J, Prange L, Boggs A, Subei M, Myers C, Uchitel J, et al.
Eur J Paediatr Neurol . 2023 Dec; 48:101-108. PMID: 38096596
Background: Non-sleep related apnea (NSA) has been observed in alternating hemiplegia of childhood (AHC) but has yet to be characterized. Goals: Investigate the following hypotheses: 1) AHC patients manifest NSA...