Mitali Sarkar-Tyson
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Explore the profile of Mitali Sarkar-Tyson including associated specialties, affiliations and a list of published articles.
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48
Citations
818
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Recent Articles
1.
Lohr T, Herbst C, Bzdyl N, Jenkins C, Scheuplein N, Sugiarto W, et al.
ACS Infect Dis
. 2024 Oct;
10(10):3681-3691.
PMID: 39357850
Since Chagas disease, melioidosis, and Legionnaires' disease are all potentially life-threatening infections, there is an urgent need for new treatment strategies. All causative agents, , , and , express a...
2.
Lohr T, Scheuplein N, Jenkins C, Norville I, Erk C, Stapf M, et al.
Arch Pharm (Weinheim)
. 2024 Apr;
357(8):e2400032.
PMID: 38687906
Due to increasing antibiotic resistance, the development of anti-infectives with new mechanisms of action is crucial. Virulence factors such as the "macrophage infectivity potentiator" (Mip) protein, which catalyzes the folding...
3.
Iwasaki J, Bzdyl N, Lin-Sullivan D, Scheuplein N, Duenas M, de Jong E, et al.
Front Cell Infect Microbiol
. 2024 Apr;
14:1353682.
PMID: 38590438
Introduction: Melioidosis, caused by the Gram-negative bacterium , is a disease endemic in many tropical countries globally. Clinical presentation is highly variable, ranging from asymptomatic to fatal septicemia, and thus...
4.
Moran C, Debowski A, Vrielink A, Stubbs K, Sarkar-Tyson M
Environ Microbiol
. 2024 Jan;
26(1):e16571.
PMID: 38178319
Burkholderia pseudomallei is a saprophytic Gram-negative bacillus that can cause the disease melioidosis. Although B. pseudomallei is a recognised member of terrestrial soil microbiomes, little is known about its contribution...
5.
Thai V, Stubbs K, Sarkar-Tyson M, Kahler C
Antibiotics (Basel)
. 2023 Sep;
12(9).
PMID: 37760679
Antibiotic resistance caused by multidrug-resistant (MDR) bacteria is a major challenge to global public health. Polymyxins are increasingly being used as last-in-line antibiotics to treat MDR Gram-negative bacterial infections, but...
6.
Debowski A, Bzdyl N, Thomas D, Scott N, Jenkins C, Iwasaki J, et al.
PLoS Pathog
. 2023 Jul;
19(7):e1011491.
PMID: 37399210
Coxiella burnetii is a Gram-negative intracellular pathogen that causes the debilitating disease Q fever, which affects both animals and humans. The only available human vaccine, Q-Vax, is effective but has...
7.
Scheuplein N, Bzdyl N, Lohr T, Kibble E, Hasenkopf A, Herbst C, et al.
J Med Chem
. 2023 Jun;
66(13):8876-8895.
PMID: 37389560
The macrophage infectivity potentiator (Mip) protein is a promising target for developing new drugs to combat antimicrobial resistance. New rapamycin-derived Mip inhibitors have been designed that may be able to...
8.
Bzdyl N, Moran C, Bendo J, Sarkar-Tyson M
Virulence
. 2022 Oct;
13(1):1945-1965.
PMID: 36271712
The soil saprophyte, , is the causative agent of melioidosis, a disease endemic in South East Asia and northern Australia. Exposure to by either inhalation or inoculation can lead to...
9.
Mullally C, Stubbs K, Thai V, Anandan A, Bartley S, Scanlon M, et al.
J Antimicrob Chemother
. 2022 Jun;
77(9):2441-2447.
PMID: 35770844
Objectives: Neisseria gonorrhoeae is an exclusively human pathogen that commonly infects the urogenital tract resulting in gonorrhoea. Empirical treatment of gonorrhoea with antibiotics has led to multidrug resistance and the...
10.
Iwasaki J, Lorimer D, Vivoli-Vega M, Kibble E, Peacock C, Abendroth J, et al.
J Antimicrob Chemother
. 2022 Mar;
77(6):1625-1634.
PMID: 35245364
Background: The macrophage infectivity potentiator (Mip) protein, which belongs to the immunophilin superfamily, is a peptidyl-prolyl cis/trans isomerase (PPIase) enzyme. Mip has been shown to be important for virulence in...