Mirna S Sadek
Overview
Explore the profile of Mirna S Sadek including associated specialties, affiliations and a list of published articles.
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Articles
5
Citations
48
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0
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Recent Articles
1.
Cachorro E, Gunscht M, Schubert M, Sadek M, Siegert J, Dutt F, et al.
Circ Res
. 2023 Jan;
132(4):400-414.
PMID: 36715019
Background: Ventricular arrhythmia and sudden cardiac death are the most common lethal complications after myocardial infarction. Antiarrhythmic pharmacotherapy remains a clinical challenge and novel concepts are highly desired. Here, we...
2.
Kunzel S, Hoffmann M, Weber S, Kunzel K, Kammerer S, Gunscht M, et al.
Circ Res
. 2021 Aug;
129(8):804-820.
PMID: 34433292
[Figure: see text].
3.
Wagner M, Sadek M, Dybkova N, Mason F, Klehr J, Firneburg R, et al.
Int J Mol Sci
. 2021 Jun;
22(9).
PMID: 34062838
Background: Phosphodiesterases (PDE) critically regulate myocardial cAMP and cGMP levels. PDE2 is stimulated by cGMP to hydrolyze cAMP, mediating a negative crosstalk between both pathways. PDE2 upregulation in heart failure...
4.
Sadek M, Cachorro E, El-Armouche A, Kammerer S
Int J Mol Sci
. 2020 Oct;
21(20).
PMID: 33050419
Phosphodiesterases (PDEs) are the principal superfamily of enzymes responsible for degrading the secondary messengers 3',5'-cyclic nucleotides cAMP and cGMP. Their refined subcellular localization and substrate specificity contribute to finely regulate...
5.
Karamitri A, Sadek M, Journe A, Gbahou F, Gerbier R, Osman M, et al.
Bioorg Chem
. 2019 Jan;
85:349-356.
PMID: 30658234
A series of dimeric melatonin analogues 3a-e obtained by connecting two melatonin molecules through the methoxy oxygen atoms with spacers spanning 16-24 atoms and the agomelatine dimer 7 were synthesized...