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Miriam Gagliardi

Explore the profile of Miriam Gagliardi including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 329
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Recent Articles
1.
Gerstner N, Frohlich A, Matosin N, Gagliardi M, Cruceanu C, Kodel M, et al.
Sci Adv . 2025 Mar; 11(10):eadq2290. PMID: 40053590
Psychiatric disorders like schizophrenia, bipolar disorder, and major depressive disorder exhibit substantial genetic and clinical overlap. However, their molecular architecture remains elusive due to their polygenic nature and complex brain...
2.
Frohlich A, Gerstner N, Gagliardi M, Kodel M, Yusupov N, Matosin N, et al.
Nat Neurosci . 2024 Sep; 27(10):2021-2032. PMID: 39227716
Aging is a complex biological process and represents the largest risk factor for neurodegenerative disorders. The risk for neurodegenerative disorders is also increased in individuals with psychiatric disorders. Here, we...
3.
Raabe F, Hausruckinger A, Gagliardi M, Ahmad R, Almeida V, Galinski S, et al.
bioRxiv . 2024 Jan; PMID: 38260577
Schizophrenia (SCZ) is a genetically heterogenous psychiatric disorder of highly polygenic nature. Correlative evidence from genetic studies indicate that the aggregated effects of distinct genetic risk factor combinations found in...
4.
Rummel C, Gagliardi M, Ahmad R, Herholt A, Jimenez-Barron L, Murek V, et al.
Cell . 2023 Oct; 186(23):5165-5182.e33. PMID: 37852259
Schizophrenia (SCZ) is a highly heritable mental disorder with thousands of associated genetic variants located mostly in the noncoding space of the genome. Translating these associations into insights regarding the...
5.
Rummel C, Gagliardi M, Herholt A, Ahmad R, Murek V, Weigert L, et al.
bioRxiv . 2023 Jul; PMID: 37425902
Schizophrenia (SCZ) is a highly polygenic disease and genome wide association studies have identified thousands of genetic variants that are statistically associated with this psychiatric disorder. However, our ability to...
6.
Matosin N, Arloth J, Czamara D, Edmond K, Maitra M, Frohlich A, et al.
Acta Neuropathol . 2023 Feb; 145(4):439-459. PMID: 36729133
Identification and characterisation of novel targets for treatment is a priority in the field of psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a...
7.
Chang S, Fermani F, Lao C, Huang L, Jakovcevski M, Di Giaimo R, et al.
Sci Adv . 2022 Nov; 8(46):eabo1023. PMID: 36383658
An adaptive stress response involves various mediators and circuits orchestrating a complex interplay of physiological, emotional, and behavioral adjustments. We identified a population of corticotropin-releasing hormone (CRH) neurons in the...
8.
Di Filippo L, Righelli D, Gagliardi M, Matarazzo M, Angelini C
Front Genet . 2019 Nov; 10:1079. PMID: 31749839
The High-throughput Chromosome Conformation Capture (Hi-C) technique combines the power of the Next Generation Sequencing technologies with chromosome conformation capture approach to study the 3D chromatin organization at the genome-wide...
9.
Toubiana S, Gagliardi M, Papa M, Manco R, Tzukerman M, Matarazzo M, et al.
Elife . 2019 Nov; 8. PMID: 31738163
DNA methyltransferase 3B (DNMT3B) is the major DNMT that methylates mammalian genomes during early development. Mutations in human disrupt genome-wide DNA methylation patterns and result in ICF syndrome type 1...
10.
DAniello C, Cermola F, Palamidessi A, Wanderlingh L, Gagliardi M, Migliaccio A, et al.
Cancer Res . 2019 May; 79(13):3235-3250. PMID: 31061065
Collagen prolyl hydroxylation (CPH), which is catalyzed by prolyl 4-hydroxylase (P4H), is the most prevalent posttranslational modification in humans and requires vitamin C (VitC). Here, we demonstrate that CPH acts...