Mindy H Hsieh
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Explore the profile of Mindy H Hsieh including associated specialties, affiliations and a list of published articles.
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6
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763
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Recent Articles
1.
Chen C, Beyer C, Liu J, Maier C, Li C, Trinh-Minh T, et al.
Ann Rheum Dis
. 2017 Feb;
76(4):773-778.
PMID: 28153829
Objectives: Wnt signalling has been implicated in activating a fibrogenic programme in fibroblasts in systemic sclerosis (SSc). Porcupine is an O-acyltransferase required for secretion of Wnt proteins in mammals. Here,...
2.
Cheng D, Liu J, Han D, Zhang G, Gao W, Hsieh M, et al.
ACS Med Chem Lett
. 2016 Jul;
7(7):676-80.
PMID: 27437076
Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. We developed and performed a cellular high-throughput screen for inhibitors of Wnt secretion and pathway activation. A...
3.
Zhou Z, Patel M, Ng N, Hsieh M, Orth A, Walker J, et al.
BMC Cancer
. 2014 Dec;
14:944.
PMID: 25495526
Background: MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC in cancer has been challenging thus far. Synthetic lethality provides...
4.
Liu J, Pan S, Hsieh M, Ng N, Sun F, Wang T, et al.
Proc Natl Acad Sci U S A
. 2013 Nov;
110(50):20224-9.
PMID: 24277854
Wnt signaling is one of the key oncogenic pathways in multiple cancers, and targeting this pathway is an attractive therapeutic approach. However, therapeutic success has been limited because of the...
5.
Jiang X, Hao H, Growney J, Woolfenden S, Bottiglio C, Ng N, et al.
Proc Natl Acad Sci U S A
. 2013 Jul;
110(31):12649-54.
PMID: 23847203
A growing number of agents targeting ligand-induced Wnt/β-catenin signaling are being developed for cancer therapy. However, clinical development of these molecules is challenging because of the lack of a genetic...
6.
Liu J, Johnson K, Li J, Piamonte V, Steffy B, Hsieh M, et al.
Proc Natl Acad Sci U S A
. 2011 Aug;
108(35):14560-5.
PMID: 21841138
Regeneration of peripheral differentiated tissue in mammals is rare, and regulators of this process are largely unknown. We carried out a forward genetic screen in mice using N-ethyl-N-nitrosourea mutagenesis to...