Min-Yeh Tsai
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Explore the profile of Min-Yeh Tsai including associated specialties, affiliations and a list of published articles.
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19
Citations
298
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Recent Articles
11.
Lin X, Kulkarni P, Bocci F, Schafer N, Roy S, Tsai M, et al.
Biomolecules
. 2019 Mar;
9(2).
PMID: 30813315
Folded proteins show a high degree of structural order and undergo (fairly constrained) collective motions related to their functions. On the other hand, intrinsically disordered proteins (IDPs), while lacking a...
12.
Lin X, Roy S, Jolly M, Bocci F, Schafer N, Tsai M, et al.
J Mol Biol
. 2018 May;
430(16):2422-2438.
PMID: 29758263
Prostate-associated gene 4 (PAGE4) is an intrinsically disordered protein implicated in prostate cancer. Thestress-response kinase homeodomain-interacting protein kinase 1 (HIPK1) phosphorylates two residues in PAGE4, serine 9 and threonine 51....
13.
Zheng W, Tsai M, Wolynes P
J Am Chem Soc
. 2017 Oct;
139(46):16666-16676.
PMID: 29057654
Using a predictive coarse-grained protein force field, we compute and compare the free energy landscapes and relative stabilities of amyloid-β protein (1-42) and amyloid-β protein (1-40) in their monomeric and...
14.
Zheng W, Tsai M, Chen M, Wolynes P
Proc Natl Acad Sci U S A
. 2016 Oct;
113(42):11835-11840.
PMID: 27698130
A predictive coarse-grained protein force field [associative memory, water-mediated, structure, and energy model for molecular dynamics (AWSEM)-MD] is used to study the energy landscapes and relative stabilities of amyloid-β protein...
15.
Tsai M, Zhang B, Zheng W, Wolynes P
J Am Chem Soc
. 2016 Sep;
138(41):13497-13500.
PMID: 27685351
Fis protein is a nucleoid-associated protein that plays many roles in transcriptional regulation and DNA site-specific recombination. In contrast to the naïve expectation based on stoichiometry, recent single-molecule studies have...
16.
Parra R, Schafer N, Radusky L, Tsai M, Guzovsky A, Wolynes P, et al.
Nucleic Acids Res
. 2016 May;
44(W1):W356-60.
PMID: 27131359
The protein frustratometer is an energy landscape theory-inspired algorithm that aims at localizing and quantifying the energetic frustration present in protein molecules. Frustration is a useful concept for analyzing proteins'...
17.
Shiu Y, Hayashi M, Shih O, Su C, Tsai M, Yeh Y, et al.
Phys Chem Chem Phys
. 2016 Jan;
18(4):3179-87.
PMID: 26743265
With a deformed object of a rigid rod inside, the local dislocations may be tracked relatively easily with respect to the internal rigid rod. We apply this concept on protein...
18.
Tsai M, Zheng W, Balamurugan D, Schafer N, Kim B, Cheung M, et al.
Protein Sci
. 2015 Jul;
25(1):255-69.
PMID: 26183799
While being long in range and therefore weakly specific, electrostatic interactions are able to modulate the stability and folding landscapes of some proteins. The relevance of electrostatic forces for steering...
19.
Tsai M, Yuan J, Teranishi Y, Lin S
J Biol Phys
. 2014 Mar;
38(4):543-71.
PMID: 24615219
Herein, we propose a modified version of the Wako-Saitô-Muñoz-Eaton (WSME) model. The proposed model introduces an empirical temperature parameter for the hypothetical structural units (i.e., foldons) in proteins to include...