Miika Martikainen
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Explore the profile of Miika Martikainen including associated specialties, affiliations and a list of published articles.
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13
Citations
427
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Recent Articles
1.
Martikainen M, Lugano R, Pietila I, Brosch S, Cabrolier C, Sivaramakrishnan A, et al.
Nat Commun
. 2024 Dec;
15(1):10718.
PMID: 39715740
Semliki Forest virus (SFV) is a neuropathogenic alphavirus which is of interest both as a model neurotropic alphavirus and as an oncolytic virus with proven potency in preclinical cancer models....
2.
Ramachandran M, Vaccaro A, van de Walle T, Georganaki M, Lugano R, Vemuri K, et al.
Cancer Cell
. 2023 May;
41(6):1134-1151.e10.
PMID: 37172581
Glioblastomas are aggressive brain tumors that are largely immunotherapy resistant. This is associated with immunosuppression and a dysfunctional tumor vasculature, which hinder T cell infiltration. LIGHT/TNFSF14 can induce high endothelial...
3.
Martikainen M, Ramachandran M, Lugano R, Ma J, Martikainen M, Dimberg A, et al.
Mol Ther Oncolytics
. 2021 Apr;
21:37-46.
PMID: 33869741
Oncolytic virotherapy holds promise of effective immunotherapy against otherwise nonresponsive cancers such as glioblastoma. Our previous findings have shown that although oncolytic Semliki Forest virus (SFV) is effective against various...
4.
Ma J, Ramachandran M, Jin C, Quijano-Rubio C, Martikainen M, Yu D, et al.
Cell Death Dis
. 2020 Jan;
11(1):48.
PMID: 31969562
Oncolytic viruses have the potential to induce immunogenic cell death (ICD) that may provoke potent and long-lasting anti-cancer immunity. Here we aimed to characterize the ICD-inducing ability of wild-type Adenovirus...
5.
Martikainen M, Essand M
Cancers (Basel)
. 2019 Feb;
11(2).
PMID: 30764570
Glioblastoma (GBM) is the most common type of primary brain tumor in adults. Despite recent advances in cancer therapy, including the breakthrough of immunotherapy, the prognosis of GBM patients remains...
6.
Saren T, Ramachandran M, Martikainen M, Yu D
Mol Ther Oncolytics
. 2017 Nov;
7:67-75.
PMID: 29159280
Oncolytic Semliki Forest virus (SFV) has been suggested as a potential candidate for the treatment of glioblastoma and neuroblastoma. However, the oncolytic capacity of SFV is restricted by the anti-viral...
7.
Bulanova D, Ianevski A, Bugai A, Akimov Y, Kuivanen S, Paavilainen H, et al.
Viruses
. 2017 Sep;
9(10).
PMID: 28946654
Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here...
8.
Niittykoski M, Von Und Zu Fraunberg M, Martikainen M, Rauramaa T, Immonen A, Koponen S, et al.
Transl Oncol
. 2017 Aug;
10(5):772-779.
PMID: 28797937
Background: Oncolytic adenoviruses show promise in targeting gliomas because they do not replicate in normal brain cells. However, clinical responses occur only in a subset of patients. One explanation could...
9.
Martikainen M, Ruotsalainen J, Tuomela J, Harkonen P, Essand M, Heikkila J, et al.
Br J Cancer
. 2017 May;
117(1):51-55.
PMID: 28557974
Background: Despite recent therapeutic and diagnostic advances, prostate cancer remains the second leading cause of cancer-related deaths among men in the Western world. Oncolytic viruses that replicate selectively in tumour...
10.
Martikainen M, Niittykoski M, Von Und Zu Fraunberg M, Immonen A, Koponen S, van Geenen M, et al.
J Virol
. 2015 Aug;
89(20):10637-47.
PMID: 26269187
Unlabelled: Glioblastoma is a terminal disease with no effective treatment currently available. Among the new therapy candidates are oncolytic viruses capable of selectively replicating in cancer cells, causing tumor lysis...