Mihajlo Filep
Overview
Explore the profile of Mihajlo Filep including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
72
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0
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Recent Articles
1.
McCorkindale W, Filep M, London N, Lee A, King-Smith E
RSC Med Chem
. 2024 Mar;
15(3):1015-1021.
PMID: 38516605
High throughput and rapid biological evaluation of small molecules is an essential factor in drug discovery and development. Direct-to-biology (D2B), whereby compound purification is foregone, has emerged as a viable...
2.
Boby M, Fearon D, Ferla M, Filep M, Koekemoer L, Robinson M, et al.
Science
. 2023 Nov;
382(6671):eabo7201.
PMID: 37943932
We report the results of the COVID Moonshot, a fully open-science, crowdsourced, and structure-enabled drug discovery campaign targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease. We discovered...
3.
Zaidman D, Gehrtz P, Filep M, Fearon D, Gabizon R, Douangamath A, et al.
Cell Chem Biol
. 2021 Jun;
28(12):1795-1806.e5.
PMID: 34174194
Designing covalent inhibitors is increasingly important, although it remains challenging. Here, we present covalentizer, a computational pipeline for identifying irreversible inhibitors based on structures of targets with non-covalent binders. Through...