Mihail Ivilinov Todorov
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Explore the profile of Mihail Ivilinov Todorov including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Khoury N, Pizzo M, Discenza C, Joy D, Tatarakis D, Todorov M, et al.
Nat Commun
. 2025 Feb;
16(1):1822.
PMID: 39979268
Blood brain barrier-crossing molecules targeting transferrin receptor (TfR) and CD98 heavy chain (CD98hc) are widely reported to promote enhanced brain delivery of therapeutics. Here, we provide a comprehensive and unbiased...
2.
Luo J, Molbay M, Chen Y, Horvath I, Kadletz K, Kick B, et al.
Nat Biotechnol
. 2025 Jan;
PMID: 39809933
Efficient and accurate nanocarrier development for targeted drug delivery is hindered by a lack of methods to analyze its cell-level biodistribution across whole organisms. Here we present Single Cell Precision...
3.
Todorov-Volgyi K, Gonzalez-Gallego J, Muller S, Beaufort N, Malik R, Schifferer M, et al.
Nat Aging
. 2024 Mar;
4(4):595-612.
PMID: 38519806
Age-related decline in brain endothelial cell (BEC) function contributes critically to neurological disease. Comprehensive atlases of the BEC transcriptome have become available, but results from proteomic profiling are lacking. To...
4.
Bhatia H, Brunner A, Ozturk F, Kapoor S, Rong Z, Mai H, et al.
Cell
. 2022 Dec;
185(26):5040-5058.e19.
PMID: 36563667
Spatial molecular profiling of complex tissues is essential to investigate cellular function in physiological and pathological states. However, methods for molecular analysis of large biological specimens imaged in 3D are ...
5.
Ramos-Vega M, Kjellman P, Todorov M, Kylkilahti T, Backstrom B, Erturk A, et al.
Acta Neuropathol Commun
. 2022 Apr;
10(1):51.
PMID: 35410629
Recent studies suggest that metabolic changes and oxygen deficiency in the central nervous system play an important role in the pathophysiology of multiple sclerosis (MS). In our present study, we...
6.
Molbay M, Kolabas Z, Todorov M, Ohn T, Erturk A
Mol Syst Biol
. 2021 Mar;
17(3):e9807.
PMID: 33769689
Histological analysis of biological tissues by mechanical sectioning is significantly time-consuming and error-prone due to loss of important information during sample slicing. In the recent years, the development of tissue...
7.
Schoppe O, Pan C, Coronel J, Mai H, Rong Z, Todorov M, et al.
Nat Commun
. 2020 Nov;
11(1):5626.
PMID: 33159057
Whole-body imaging of mice is a key source of information for research. Organ segmentation is a prerequisite for quantitative analysis but is a tedious and error-prone task if done manually....
8.
Ravasz L, Kekesi K, Mittli D, Todorov M, Borhegyi Z, Ercsey-Ravasz M, et al.
Cereb Cortex
. 2020 Jul;
31(2):731-745.
PMID: 32710103
The prefrontal cortex (PFC) plays a key role in higher order cognitive functions and psychiatric disorders such as autism, schizophrenia, and depression. In the PFC, the two major classes of...
9.
Todorov M, Paetzold J, Schoppe O, Tetteh G, Shit S, Efremov V, et al.
Nat Methods
. 2020 Mar;
17(4):442-449.
PMID: 32161395
Tissue clearing methods enable the imaging of biological specimens without sectioning. However, reliable and scalable analysis of large imaging datasets in three dimensions remains a challenge. Here we developed a...
10.
Zhao S, Todorov M, Cai R, -Maskari R, Steinke H, Kemter E, et al.
Cell
. 2020 Feb;
180(4):796-812.e19.
PMID: 32059778
Optical tissue transparency permits scalable cellular and molecular investigation of complex tissues in 3D. Adult human organs are particularly challenging to render transparent because of the accumulation of dense and...