Miguel A Gonzalez-Lozano
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Explore the profile of Miguel A Gonzalez-Lozano including associated specialties, affiliations and a list of published articles.
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19
Citations
188
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Recent Articles
1.
Gonzalez-Lozano M, Schmid E, Whelan E, Jiang Y, Paulo J, Walter J, et al.
bioRxiv
. 2025 Feb;
PMID: 39975243
Early/sorting endosomes are dynamic organelles that play key roles in proteome control by triaging plasma membrane proteins for either recycling or degradation in the lysosome. These events are coordinated by...
2.
Hundley F, Gonzalez-Lozano M, Gottschalk L, Cook A, Zhang J, Paulo J, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(52):e2419079121.
PMID: 39636867
Plasma membrane protein degradation and recycling are regulated by the endolysosomal system, wherein endocytic vesicles bud from the plasma membrane into the cytoplasm and mature into endosomes and then degradative...
3.
Hundley F, Gonzalez-Lozano M, Gottschalk L, Cook A, Zhang J, Paulo J, et al.
bioRxiv
. 2024 Oct;
PMID: 39386502
Plasma membrane protein degradation and recycling is regulated by the endolysosomal system, wherein endosomes bud from the plasma membrane into the cytosol and mature into degradative lysosomes. As such, the...
4.
Hoyer M, Capitanio C, Smith I, Paoli J, Bieber A, Jiang Y, et al.
Nat Cell Biol
. 2024 Mar;
26(3):378-392.
PMID: 38429475
The endoplasmic reticulum (ER) employs a diverse proteome landscape to orchestrate many cellular functions, ranging from protein and lipid synthesis to calcium ion flux and inter-organelle communication. A case in...
5.
Chen M, Koopmans F, Gonzalez-Lozano M, Smit A, Li K
Cells
. 2024 Jan;
13(1).
PMID: 38201218
GABA receptors are the major inhibitory receptors in the brain. They are hetero-pentamers with a composition of predominantly two α, two β, and one γ or δ subunit. Of the...
6.
Subkhangulova A, Gonzalez-Lozano M, Groffen A, van Weering J, Smit A, Toonen R, et al.
Elife
. 2023 Sep;
12.
PMID: 37695731
Tomosyn is a large, non-canonical SNARE protein proposed to act as an inhibitor of SNARE complex formation in the exocytosis of secretory vesicles. In the brain, tomosyn inhibits the fusion...
7.
Hoyer M, Capitanio C, Smith I, Paoli J, Bieber A, Jiang Y, et al.
bioRxiv
. 2023 Jul;
PMID: 37425907
The endoplasmic reticulum (ER) employs a diverse proteome landscape to orchestrate many cellular functions ranging from protein and lipid synthesis to calcium ion flux and inter-organelle communication. A case in...
8.
Pintacuda G, Hsu Y, Tsafou K, Li K, Martin J, Riseman J, et al.
Cell Genom
. 2023 Mar;
3(3):100250.
PMID: 36950384
Autism spectrum disorders (ASDs) have been linked to genes with enriched expression in the brain, but it is unclear how these genes converge into cell-type-specific networks. We built a protein-protein...
9.
Louros S, Seo S, Maio B, Martinez-Gonzalez C, Gonzalez-Lozano M, Muscas M, et al.
Neuron
. 2022 Dec;
111(4):508-525.e7.
PMID: 36495869
In fragile X syndrome (FX), the leading monogenic cause of autism, excessive neuronal protein synthesis is a core pathophysiology; however, an overall increase in protein expression is not observed. Here,...
10.
Seo S, Louros S, Anstey N, Gonzalez-Lozano M, Harper C, Verity N, et al.
Nat Commun
. 2022 Jun;
13(1):3236.
PMID: 35688821
Dysregulated protein synthesis is a core pathogenic mechanism in Fragile X Syndrome (FX). The mGluR Theory of FX predicts that pathological synaptic changes arise from the excessive translation of mRNAs...