Michelle Sparman
Overview
Explore the profile of Michelle Sparman including associated specialties, affiliations and a list of published articles.
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12
Citations
1073
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Recent Articles
1.
Ma H, Morey R, ONeil R, He Y, Daughtry B, Schultz M, et al.
Nature
. 2014 Jul;
511(7508):177-83.
PMID: 25008523
Human pluripotent stem cells hold potential for regenerative medicine, but available cell types have significant limitations. Although embryonic stem cells (ES cells) from in vitro fertilized embryos (IVF ES cells)...
2.
Kang E, Wu G, Ma H, Li Y, Tippner-Hedges R, Tachibana M, et al.
Nature
. 2014 Mar;
509(7498):101-4.
PMID: 24670652
Successful mammalian cloning using somatic cell nuclear transfer (SCNT) into unfertilized, metaphase II (MII)-arrested oocytes attests to the cytoplasmic presence of reprogramming factors capable of inducing totipotency in somatic cell...
3.
Amato P, Tachibana M, Sparman M, Mitalipov S
Fertil Steril
. 2014 Jan;
101(1):31-5.
PMID: 24382342
The exchange of nuclear genetic material between oocytes and embryos offers a novel reproductive option for the prevention of inherited mitochondrial diseases. Mitochondrial dysfunction has been recognized as a significant...
4.
Tachibana M, Amato P, Sparman M, Marti Gutierrez N, Tippner-Hedges R, Ma H, et al.
Cell
. 2013 May;
153(6):1228-38.
PMID: 23683578
Reprogramming somatic cells into pluripotent embryonic stem cells (ESCs) by somatic cell nuclear transfer (SCNT) has been envisioned as an approach for generating patient-matched nuclear transfer (NT)-ESCs for studies of...
5.
Tachibana M, Amato P, Sparman M, Woodward J, Melguizo Sanchis D, Ma H, et al.
Nature
. 2012 Oct;
493(7434):627-31.
PMID: 23103867
Mutations in mitochondrial DNA (mtDNA) are associated with severe human diseases and are maternally inherited through the egg's cytoplasm. Here we investigated the feasibility of mtDNA replacement in human oocytes...
6.
Lee H, Ma H, Juanes R, Tachibana M, Sparman M, Woodward J, et al.
Cell Rep
. 2012 Jun;
1(5):506-15.
PMID: 22701816
The timing and mechanisms of mitochondrial DNA (mtDNA) segregation and transmission in mammals are poorly understood. Genetic bottleneck in female germ cells has been proposed as the main phenomenon responsible...
7.
Tachibana M, Sparman M, Mitalipov S
Fertil Steril
. 2012 May;
97(5):e16.
PMID: 22542144
Objective: To demonstrate step-by-step micromanipulation procedures required for transfer of spindle-chromosomal complexes between mature oocytes. Design: Video presentation of reproductive biology study. Setting: In vitro fertilization and embryo manipulation laboratory....
8.
Tachibana M, Sparman M, Ramsey C, Ma H, Lee H, Penedo M, et al.
Cell
. 2012 Jan;
148(1-2):285-95.
PMID: 22225614
Totipotent cells in early embryos are progenitors of all stem cells and are capable of developing into a whole organism, including extraembryonic tissues such as placenta. Pluripotent cells in the...
9.
Tachibana M, Sparman M, Mitalipov S
Nat Protoc
. 2010 Jun;
5(6):1138-47.
PMID: 20539289
In this article, we describe detailed protocols for the isolation and transfer of spindle-chromosomal complexes between mature, metaphase II-arrested oocytes. In brief, the spindle-chromosomal complex is visualized using a polarized...
10.
Sritanaudomchai H, Sparman M, Tachibana M, Clepper L, Woodward J, Gokhale S, et al.
Dev Biol
. 2009 Sep;
335(1):179-87.
PMID: 19733166
The first lineage decision during mammalian development is the establishment of the trophectoderm (TE) and the inner cell mass (ICM). The caudal-type homeodomain protein Cdx2 is implicated in the formation...